Regioselective Carbonylation of 2,2-Disubstituted Epoxides: An Alternative Route to Ketone-Based Aldol Products

We report the regioselective carbonylation of 2,2-disubstituted epoxides to β,β-disubstituted β-lactones. Mechanistic studies revealed epoxide ring-opening as the turnover limiting step, an insight that facilitated the development of improved reaction conditions using weakly donating, ethereal solve...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-02, Vol.141 (6), p.2474-2480
Hauptverfasser:	Hubbell, Aran K, LaPointe, Anne M, Lamb, Jessica R, Coates, Geoffrey W
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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