A bifunctional salvage pathway for two distinct S‐adenosylmethionine by‐products that is widespread in bacteria, including pathogenic Escherichia coli

S‐adenosyl‐l‐methionine (SAM) is a necessary cosubstrate for numerous essential enzymatic reactions including protein and nucleotide methylations, secondary metabolite synthesis and radical‐mediated processes. Radical SAM enzymes produce 5ʹ‐deoxyadenosine, and SAM‐dependent enzymes for polyamine, ne...

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Veröffentlicht in:	Molecular microbiology 2020-05, Vol.113 (5), p.923-937
Hauptverfasser:	North, Justin A., Wildenthal, John A., Erb, Tobias J., Evans, Bradley S., Byerly, Kathryn M., Gerlt, John A., Tabita, Fred R.
Format:	Artikel
Sprache:	eng
Schlagworte:	09 BIOMASS FUELS 60 APPLIED LIFE SCIENCES Acetaldehyde Adenine Adenosylmethionine Aldolase Anaerobic conditions Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES Carbon - metabolism Coliforms Deoxyadenosine Deoxyadenosines - metabolism Dihydroxyacetone Dihydroxyacetone Phosphate Dihydroxyacetone Phosphate - metabolism E coli ENVIRONMENTAL SCIENCES Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Extraintestinal Pathogenic Escherichia coli Fructose-Bisphosphate Aldolase - genetics Fructose-Bisphosphate Aldolase - metabolism Growth conditions Homology Isomerases - genetics Isomerases - metabolism Kinases Metabolic Networks and Pathways - genetics Metabolites Methionine Methionine - metabolism N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Neurotransmitters Nucleotides Oxygen Oxygen - metabolism Phosphorylase Phosphorylases Phosphorylases - genetics Phosphorylases - metabolism Phosphotransferases - genetics Phosphotransferases - metabolism Polyamines Quorum sensing Rhodospirillum rubrum Rhodospirillum rubrum - genetics Rhodospirillum rubrum - metabolism S-Adenosylmethionine S-Adenosylmethionine - metabolism Sulfur Thionucleosides - metabolism
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