Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its substrate PRPP. Intriguingly, HPRT regulation by...

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Veröffentlicht in:	eLife 2019-09, Vol.8 (2019)
Hauptverfasser:	Anderson, Brent W., Liu, Kuanqing, Wolak, Christine, Dubiel, Katarzyna, She, Fukang, Satyshur, Kenneth A., Keck, James L., Wang, Jue D.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES
Online-Zugang:	Volltext
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