Chemomechanical Coupling in Hexameric Protein–Protein Interfaces Harnesses Energy within V‑Type ATPases

ATP synthase is the most prominent bioenergetic macromolecular motor in all life forms, utilizing the proton gradient across the cell membrane to fuel the synthesis of ATP. Notwithstanding the wealth of available biochemical and structural information inferred from years of experiments, the precise...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-01, Vol.139 (1), p.293-310
Hauptverfasser:	Singharoy, Abhishek, Chipot, Christophe, Moradi, Mahmoud, Schulten, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Chemistry Enterococcus hirae - enzymology Hydrolysis Models, Molecular Protein Binding Vacuolar Proton-Translocating ATPases - chemistry Vacuolar Proton-Translocating ATPases - metabolism
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