Identification of AHCY inhibitors using novel high-throughput mass spectrometry

S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and l-homocysteine. This enzyme is frequently overexpressed in many tumor types and is considered to be a validated anti-tumor target. In order to enable the development of small...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-09, Vol.491 (1), p.1-7
Hauptverfasser:	Uchiyama, Noriko, Dougan, Douglas R., Lawson, J. David, Kimura, Hitomi, Matsumoto, Shin-ichi, Tanaka, Yukiya, Kawamoto, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylhomocysteinase - antagonists & inhibitors Adenosylhomocysteinase - metabolism Antineoplastic Agents - analysis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites Cell Survival - drug effects Drug Evaluation, Preclinical Enzyme Inhibitors - analysis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology HCT116 Cells High-throughput mass spectrometry (HTMS) High-Throughput Screening Assays Humans Inhibitor Mass Spectrometry Protein Binding Protein Interaction Maps S-adenosylhomocysteine hydrolase (AHCY)
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