Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4). Furthermore, the NGF antibody tanezumab has provided clinical proof of concept fo...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-04, Vol.62 (1)
Hauptverfasser:	Bagal, Sharan K., Omoto, Kiyoyuki, Blakemore, David C., Bungay, Peter J., Bilsland, James G., Clarke, Philip J., Corbett, Matthew S., Cronin, Ciaran N., Cui, J. Jean, Dias, Rebecca, Flanagan, Neil J., Greasley, Samantha E., Grimley, Rachel, Johnson, Eric, Fengas, David, Kitching, Linda, Kraus, Michelle L., McAlpine, Indrawan, Nagata, Asako, Waldron, Gareth J., Warmus, Joseph S.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Inhibitors Ligands Molecules Peptides and proteins Selectivity
Online-Zugang:	Volltext
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