OptSSeq explores enzyme expression and function landscapes to maximize isobutanol production rate

Efficient microbial production of the next-generation biofuel isobutanol (IBA) is limited by metabolic bottlenecks. Overcoming these bottlenecks will be aided by knowing the optimal ratio of enzymes for efficient flux through the IBA biosynthetic pathway. OptSSeq (Optimization by Selection and Seque...

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Veröffentlicht in:	Metabolic engineering 2019-03, Vol.52 (C), p.324-340
Hauptverfasser:	Ghosh, Indro N., Martien, Julia, Hebert, Alexander S., Zhang, Yaoping, Coon, Joshua J., Amador-Noguez, Daniel, Landick, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Biofuels Butanols Combinatorial Optimization Isobutanol RBS Synthetic Biology
Online-Zugang:	Volltext
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