Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain

Proprotein convertase subtilisin/kexin 9 (PCSK9) is a key regulator of lipid metabolism by degrading liver LDL receptors. Structural studies have provided molecular details of PCSK9 function. However, the N-terminal acidic stretch of the PCSK9 prodomain (Q31–T60) has eluded structural investigation,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2019-03, Vol.431 (5), p.885-903
Hauptverfasser:	Ultsch, M., Li, W., Eigenbrot, C., Di Lello, P., Lipari, M.T., Gerhardy, S., AhYoung, A.P., Quinn, J., Franke, Y., Chen, Y., Kong Beltran, M., Peterson, A., Kirchhofer, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line, Tumor Crystallography, X-Ray - methods Hep G2 Cells Humans intrinsically disordered regions LDL receptor molecular recognition motif Mutation, Missense - genetics Peptides - genetics posttranslational modifications proprotein convertase Proprotein Convertase 9 - genetics Protein Processing, Post-Translational - genetics Receptors, LDL - genetics Serine Endopeptidases - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!