Copper‐Catalyzed C(sp3)−H Amidation: Sterically Driven Primary and Secondary C−H Site‐Selectivity

Undirected C(sp3)−H functionalization reactions often follow site‐selectivity patterns that mirror the corresponding C−H bond dissociation energies (BDEs). This often results in the functionalization of weaker tertiary C−H bonds in the presence of stronger secondary and primary bonds. An important,...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2019-03, Vol.58 (11), p.3421-3425
Hauptverfasser:	Bakhoda, Abolghasem (Gus), Jiang, Quan, Badiei, Yosra M., Bertke, Jeffery A., Cundari, Thomas R., Warren, Timothy H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bonding strength Catalysis Catalysts Copper Cyclic hydrocarbons C−H functionalization Hydrogen bonds Intermediates nitrenes Radicals Selectivity site-selectivity Substrates
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