P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides

Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Many biosynthetic enzymes for RiPPs, especially thiopeptides, are promiscuous and can accept a wide range of peptide substrates with different amino acid sequences; thus, th...

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Veröffentlicht in:	ACS chemical biology 2017-07, Vol.12 (7), p.1726-1731
Hauptverfasser:	Gober, Joshua G, Ghodge, Swapnil V, Bogart, Jonathan W, Wever, Walter J, Watkins, Richard R, Brustad, Eric M, Bowers, Albert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemistry BASIC BIOLOGICAL SCIENCES Cyclopropanation Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Hydrocarbons INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Modification Peptides - chemistry Peptides - metabolism Peptides and proteins Pharmaceuticals Propane - chemistry Propane - metabolism Protein Processing, Post-Translational Ribosomes - metabolism Sulfhydryl Compounds - chemistry
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