Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction wit...

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Veröffentlicht in:	Cancer cell 2016-02, Vol.29 (2), p.173-185
Hauptverfasser:	Grandin, Mélodie, Meier, Markus, Delcros, Jean Guy, Nikodemus, Denise, Reuten, Raphael, Patel, Trushar R., Goldschneider, David, Orriss, George, Krahn, Natalie, Boussouar, Amina, Abes, Riad, Dean, Yann, Neves, David, Bernet, Agnes, Depil, Stephane, Schneiders, Fiona, Poole, Kate, Dante, Robert, Koch, Manuel, Mehlen, Patrick, Stetefeld, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Humans Life Sciences Mice Mice, Nude Models, Molecular Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Nerve Growth Factors - immunology Nerve Growth Factors - metabolism Netrin Receptors Netrin-1 Protein Binding Receptors, Cell Surface - metabolism Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - metabolism
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