Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to nutrients, energy levels, and growth factors. It contains the atypical kinase mTOR and the RAPTOR subunit that binds to the Tor signalling sequence (TOS) motif of substrates and regulators. mTOR...

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Veröffentlicht in:	Nature (London) 2017-12, Vol.552 (7685), p.368-373
Hauptverfasser:	Yang, Haijuan, Jiang, Xiaolu, Li, Buren, Yang, Hyo J., Miller, Meredith, Yang, Angela, Dhar, Ankita, Pavletich, Nikola P.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/45/275 631/535/1258/1259 631/67/395 631/80/83/2359 Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Amino Acid Motifs BASIC BIOLOGICAL SCIENCES Binding Sites Biocatalysis Catalytic Domain Cryoelectron Microscopy Crystallography, X-Ray Enzyme Activation GTPases Humanities and Social Sciences Humans Kinases Mechanistic Target of Rapamycin Complex 1 - agonists Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors Mechanistic Target of Rapamycin Complex 1 - chemistry Mechanistic Target of Rapamycin Complex 1 - ultrastructure Models, Molecular multidisciplinary Mutation Neoplasms - genetics Oncogenes Protein Binding Protein Domains Protein kinases Protein research Ras Homolog Enriched in Brain Protein - chemistry Ras Homolog Enriched in Brain Protein - metabolism Ras Homolog Enriched in Brain Protein - ultrastructure Regulatory-Associated Protein of mTOR - chemistry Regulatory-Associated Protein of mTOR - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Science Signal Transduction Sirolimus - metabolism Substrate Specificity Tacrolimus Binding Protein 1A - metabolism TOR signalling
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