Polypeptoid polymers: Synthesis, characterization, and properties
Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and...
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| Veröffentlicht in: | Biopolymers 2018-01, Vol.109 (1), p.n/a |
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| container_title | Biopolymers |
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| creator | Chan, Brandon A. Xuan, Sunting Li, Ang Simpson, Jessica M. Sternhagen, Garrett L. Yu, Tianyi Darvish, Omead A. Jiang, Naisheng Zhang, Donghui |
| description | Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and adjustment of a variety of physicochemical and biological properties (eg, solubility, charge characteristics, chain conformation, HLB, thermal processability, degradability, cytotoxicity and immunogenicity). These attributes have made this synthetic polymer platform a potential candidate for various biomedical and biotechnological applications. This review will provide an overview of recent development in synthetic methods to access polypeptoid polymers with well‐defined structures and highlight some of the fundamental physicochemical and biological properties of polypeptoids that are pertinent to the future development of functional materials based on polypeptoids. |
| doi_str_mv | 10.1002/bip.23070 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Molecular Structure Peptides - chemical synthesis Peptides - chemistry Peptidomimetics - chemical synthesis Peptidomimetics - chemistry |
| title | Polypeptoid polymers: Synthesis, characterization, and properties |
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