Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica

ABSTRACT Microbially derived lipids have recently attracted renewed interests due to their broad applications in production of green diesels, cosmetic additives, and oleochemicals. Metabolic engineering efforts have targeted a large portfolio of biosynthetic pathways to efficiently convert sugar to...

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Veröffentlicht in:	Biotechnology and bioengineering 2017-07, Vol.114 (7), p.1521-1530
Hauptverfasser:	Xu, Peng, Qiao, Kangjian, Stephanopoulos, Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase aldehyde detoxification Aldehydes - metabolism Bioengineering Biofuels Bioreactors Biorefineries Cytology Dehydrogenase Dehydrogenases Disulfide reductase Fatty acids Fitness fungal morphology Gene Expression Regulation, Fungal - genetics Genetic Enhancement - methods Glucose 6 phosphate dehydrogenase Glucose-6-phosphate Glucosephosphate dehydrogenase Glutathione Lipid metabolism Lipid Metabolism - physiology Lipids Lipids - biosynthesis Lipids - genetics lipogenic pathway Metabolic engineering Metabolic Networks and Pathways - physiology Metabolism Oil Oxidative stress Oxidative Stress - physiology Phosphate Productivity Reactive oxygen species Sugar Sustainable development Yarrowia - cytology Yarrowia - physiology Yarrowia lipolytica Yeasts
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