Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195
The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type a...
Gespeichert in:
Veröffentlicht in: | Medical physics (Lancaster) 2015-10, Vol.42 (10), p.5679-5691 |
---|---|
Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 5691 |
---|---|
container_issue | 10 |
container_start_page | 5679 |
container_title | Medical physics (Lancaster) |
container_volume | 42 |
creator | Sechopoulos, Ioannis Ali, Elsayed S. M. Badal, Andreu Badano, Aldo Boone, John M. Kyprianou, Iacovos S. Mainegra‐Hing, Ernesto McMillan, Kyle L. McNitt‐Gray, Michael F. Rogers, D. W. O. Samei, Ehsan Turner, Adam C. |
description | The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type and degree of validation required depends on the goals of the research project, but, typically, such validation involves either comparison of simulation results to physical measurements or to previously published results obtained with established Monte Carlo codes. The former is complicated due to nuances of experimental conditions and uncertainty, while the latter is challenging due to typical graphical presentation and lack of simulation details in previous publications. In addition, entering the field of Monte Carlo simulations in general involves a steep learning curve. It is not a simple task to learn how to program and interpret a Monte Carlo simulation, even when using one of the publicly available code packages. This Task Group report provides a common reference for benchmarking Monte Carlo simulations across a range of Monte Carlo codes and simulation scenarios. In the report, all simulation conditions are provided for six different Monte Carlo simulation cases that involve common x‐ray based imaging research areas. The results obtained for the six cases using four publicly available Monte Carlo software packages are included in tabular form. In addition to a full description of all simulation conditions and results, a discussion and comparison of results among the Monte Carlo packages and the lessons learned during the compilation of these results are included. This abridged version of the report includes only an introductory description of the six cases and a brief example of the results of one of the cases. This work provides an investigator the necessary information to benchmark his/her Monte Carlo simulation software against the reference cases included here before performing his/her own novel research. In addition, an investigator entering the field of Monte Carlo simulations can use these descriptions and results as a self‐teaching tool to ensure that he/she is able to perform a specific simulation correctly. Finally, educators can assign these cases as learning projects as part of course objectives or training programs. |
doi_str_mv | 10.1118/1.4928676 |
format | Article |
fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_1401394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718910067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3856-8772d88745c20c9f22508017f6a553223745ce694a1756d302bf611cb332da4c3</originalsourceid><addsrcrecordid>eNp1kU1PGzEQhi3UqqTQA3-gsnpqDwv-9rq3KKIUiQiE4Gw53lnisrsOtrctp_71bprQG6fRaJ55Du-L0Aklp5TS-oyeCsNqpdUBmjGheSUYMW_QjBAjKiaIPETvc_5BCFFcknfokCnBDBNshv4s41AAL1zqIk7QQoLBA25ccThDybiNCYfePYThYbpncMmvv-Lz3-DHEn4CzmPfu_SMY4vLGiZkE1PZbvP5zRLf7j_wIvZ9KAUA37n8iC9SHDeYGnmM3rauy_BhP4_Q_bfzu8X36ur64nIxv6o8r6Wqaq1ZU9daSM-INy1jktSE6lY5KTljfHsBZYSjWqqGE7ZqFaV-xTlrnPD8CH3aeWMuwWYfCvi1j8MAvlgqCOVGTNDnHbRJ8WmEXGwfsoeucwPEMVuqaW3olKKe0C871KeY8xSc3aSwDcJSYrelWGr3pUzsx712XPXQ_CdfWpiAagf8Ch08v26yy5t_wr9_R5G3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1718910067</pqid></control><display><type>article</type><title>Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Sechopoulos, Ioannis ; Ali, Elsayed S. M. ; Badal, Andreu ; Badano, Aldo ; Boone, John M. ; Kyprianou, Iacovos S. ; Mainegra‐Hing, Ernesto ; McMillan, Kyle L. ; McNitt‐Gray, Michael F. ; Rogers, D. W. O. ; Samei, Ehsan ; Turner, Adam C.</creator><creatorcontrib>Sechopoulos, Ioannis ; Ali, Elsayed S. M. ; Badal, Andreu ; Badano, Aldo ; Boone, John M. ; Kyprianou, Iacovos S. ; Mainegra‐Hing, Ernesto ; McMillan, Kyle L. ; McNitt‐Gray, Michael F. ; Rogers, D. W. O. ; Samei, Ehsan ; Turner, Adam C.</creatorcontrib><description>The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type and degree of validation required depends on the goals of the research project, but, typically, such validation involves either comparison of simulation results to physical measurements or to previously published results obtained with established Monte Carlo codes. The former is complicated due to nuances of experimental conditions and uncertainty, while the latter is challenging due to typical graphical presentation and lack of simulation details in previous publications. In addition, entering the field of Monte Carlo simulations in general involves a steep learning curve. It is not a simple task to learn how to program and interpret a Monte Carlo simulation, even when using one of the publicly available code packages. This Task Group report provides a common reference for benchmarking Monte Carlo simulations across a range of Monte Carlo codes and simulation scenarios. In the report, all simulation conditions are provided for six different Monte Carlo simulation cases that involve common x‐ray based imaging research areas. The results obtained for the six cases using four publicly available Monte Carlo software packages are included in tabular form. In addition to a full description of all simulation conditions and results, a discussion and comparison of results among the Monte Carlo packages and the lessons learned during the compilation of these results are included. This abridged version of the report includes only an introductory description of the six cases and a brief example of the results of one of the cases. This work provides an investigator the necessary information to benchmark his/her Monte Carlo simulation software against the reference cases included here before performing his/her own novel research. In addition, an investigator entering the field of Monte Carlo simulations can use these descriptions and results as a self‐teaching tool to ensure that he/she is able to perform a specific simulation correctly. Finally, educators can assign these cases as learning projects as part of course objectives or training programs.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4928676</identifier><identifier>PMID: 26429242</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>Benchmarking ; Biological material, e.g. blood, urine; Haemocytometers ; Breast ; Computed tomography ; Computerised tomographs ; computerised tomography ; diagnostic imaging ; diagnostic radiography ; Digital computing or data processing equipment or methods, specially adapted for specific applications ; Digital tomosynthesis mammography ; EGSnrc ; geant4 ; Humans ; mammography ; mcnp ; medical computing ; Medical X‐ray imaging ; Monte Carlo Method ; Monte Carlo methods ; Monte Carlo simulation ; Monte Carlo simulations ; penelope ; Photons ; Radiography ; Reference Standards ; Research Report ; test cases ; Tomography, X-Ray Computed ; X‐ray imaging ; X‐ray scattering ; X‐ray spectra ; x‐rays</subject><ispartof>Medical physics (Lancaster), 2015-10, Vol.42 (10), p.5679-5691</ispartof><rights>2015 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3856-8772d88745c20c9f22508017f6a553223745ce694a1756d302bf611cb332da4c3</citedby><cites>FETCH-LOGICAL-c3856-8772d88745c20c9f22508017f6a553223745ce694a1756d302bf611cb332da4c3</cites><orcidid>0000-0003-3712-6670 ; 0000000337126670</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4928676$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4928676$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26429242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1401394$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sechopoulos, Ioannis</creatorcontrib><creatorcontrib>Ali, Elsayed S. M.</creatorcontrib><creatorcontrib>Badal, Andreu</creatorcontrib><creatorcontrib>Badano, Aldo</creatorcontrib><creatorcontrib>Boone, John M.</creatorcontrib><creatorcontrib>Kyprianou, Iacovos S.</creatorcontrib><creatorcontrib>Mainegra‐Hing, Ernesto</creatorcontrib><creatorcontrib>McMillan, Kyle L.</creatorcontrib><creatorcontrib>McNitt‐Gray, Michael F.</creatorcontrib><creatorcontrib>Rogers, D. W. O.</creatorcontrib><creatorcontrib>Samei, Ehsan</creatorcontrib><creatorcontrib>Turner, Adam C.</creatorcontrib><title>Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type and degree of validation required depends on the goals of the research project, but, typically, such validation involves either comparison of simulation results to physical measurements or to previously published results obtained with established Monte Carlo codes. The former is complicated due to nuances of experimental conditions and uncertainty, while the latter is challenging due to typical graphical presentation and lack of simulation details in previous publications. In addition, entering the field of Monte Carlo simulations in general involves a steep learning curve. It is not a simple task to learn how to program and interpret a Monte Carlo simulation, even when using one of the publicly available code packages. This Task Group report provides a common reference for benchmarking Monte Carlo simulations across a range of Monte Carlo codes and simulation scenarios. In the report, all simulation conditions are provided for six different Monte Carlo simulation cases that involve common x‐ray based imaging research areas. The results obtained for the six cases using four publicly available Monte Carlo software packages are included in tabular form. In addition to a full description of all simulation conditions and results, a discussion and comparison of results among the Monte Carlo packages and the lessons learned during the compilation of these results are included. This abridged version of the report includes only an introductory description of the six cases and a brief example of the results of one of the cases. This work provides an investigator the necessary information to benchmark his/her Monte Carlo simulation software against the reference cases included here before performing his/her own novel research. In addition, an investigator entering the field of Monte Carlo simulations can use these descriptions and results as a self‐teaching tool to ensure that he/she is able to perform a specific simulation correctly. Finally, educators can assign these cases as learning projects as part of course objectives or training programs.</description><subject>Benchmarking</subject><subject>Biological material, e.g. blood, urine; Haemocytometers</subject><subject>Breast</subject><subject>Computed tomography</subject><subject>Computerised tomographs</subject><subject>computerised tomography</subject><subject>diagnostic imaging</subject><subject>diagnostic radiography</subject><subject>Digital computing or data processing equipment or methods, specially adapted for specific applications</subject><subject>Digital tomosynthesis mammography</subject><subject>EGSnrc</subject><subject>geant4</subject><subject>Humans</subject><subject>mammography</subject><subject>mcnp</subject><subject>medical computing</subject><subject>Medical X‐ray imaging</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo methods</subject><subject>Monte Carlo simulation</subject><subject>Monte Carlo simulations</subject><subject>penelope</subject><subject>Photons</subject><subject>Radiography</subject><subject>Reference Standards</subject><subject>Research Report</subject><subject>test cases</subject><subject>Tomography, X-Ray Computed</subject><subject>X‐ray imaging</subject><subject>X‐ray scattering</subject><subject>X‐ray spectra</subject><subject>x‐rays</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PGzEQhi3UqqTQA3-gsnpqDwv-9rq3KKIUiQiE4Gw53lnisrsOtrctp_71bprQG6fRaJ55Du-L0Aklp5TS-oyeCsNqpdUBmjGheSUYMW_QjBAjKiaIPETvc_5BCFFcknfokCnBDBNshv4s41AAL1zqIk7QQoLBA25ccThDybiNCYfePYThYbpncMmvv-Lz3-DHEn4CzmPfu_SMY4vLGiZkE1PZbvP5zRLf7j_wIvZ9KAUA37n8iC9SHDeYGnmM3rauy_BhP4_Q_bfzu8X36ur64nIxv6o8r6Wqaq1ZU9daSM-INy1jktSE6lY5KTljfHsBZYSjWqqGE7ZqFaV-xTlrnPD8CH3aeWMuwWYfCvi1j8MAvlgqCOVGTNDnHbRJ8WmEXGwfsoeucwPEMVuqaW3olKKe0C871KeY8xSc3aSwDcJSYrelWGr3pUzsx712XPXQ_CdfWpiAagf8Ch08v26yy5t_wr9_R5G3</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Sechopoulos, Ioannis</creator><creator>Ali, Elsayed S. M.</creator><creator>Badal, Andreu</creator><creator>Badano, Aldo</creator><creator>Boone, John M.</creator><creator>Kyprianou, Iacovos S.</creator><creator>Mainegra‐Hing, Ernesto</creator><creator>McMillan, Kyle L.</creator><creator>McNitt‐Gray, Michael F.</creator><creator>Rogers, D. W. O.</creator><creator>Samei, Ehsan</creator><creator>Turner, Adam C.</creator><general>American Association of Physicists in Medicine</general><general>Wiley Blackwell (John Wiley & Sons)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0003-3712-6670</orcidid><orcidid>https://orcid.org/0000000337126670</orcidid></search><sort><creationdate>201510</creationdate><title>Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195</title><author>Sechopoulos, Ioannis ; Ali, Elsayed S. M. ; Badal, Andreu ; Badano, Aldo ; Boone, John M. ; Kyprianou, Iacovos S. ; Mainegra‐Hing, Ernesto ; McMillan, Kyle L. ; McNitt‐Gray, Michael F. ; Rogers, D. W. O. ; Samei, Ehsan ; Turner, Adam C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3856-8772d88745c20c9f22508017f6a553223745ce694a1756d302bf611cb332da4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Benchmarking</topic><topic>Biological material, e.g. blood, urine; Haemocytometers</topic><topic>Breast</topic><topic>Computed tomography</topic><topic>Computerised tomographs</topic><topic>computerised tomography</topic><topic>diagnostic imaging</topic><topic>diagnostic radiography</topic><topic>Digital computing or data processing equipment or methods, specially adapted for specific applications</topic><topic>Digital tomosynthesis mammography</topic><topic>EGSnrc</topic><topic>geant4</topic><topic>Humans</topic><topic>mammography</topic><topic>mcnp</topic><topic>medical computing</topic><topic>Medical X‐ray imaging</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo methods</topic><topic>Monte Carlo simulation</topic><topic>Monte Carlo simulations</topic><topic>penelope</topic><topic>Photons</topic><topic>Radiography</topic><topic>Reference Standards</topic><topic>Research Report</topic><topic>test cases</topic><topic>Tomography, X-Ray Computed</topic><topic>X‐ray imaging</topic><topic>X‐ray scattering</topic><topic>X‐ray spectra</topic><topic>x‐rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sechopoulos, Ioannis</creatorcontrib><creatorcontrib>Ali, Elsayed S. M.</creatorcontrib><creatorcontrib>Badal, Andreu</creatorcontrib><creatorcontrib>Badano, Aldo</creatorcontrib><creatorcontrib>Boone, John M.</creatorcontrib><creatorcontrib>Kyprianou, Iacovos S.</creatorcontrib><creatorcontrib>Mainegra‐Hing, Ernesto</creatorcontrib><creatorcontrib>McMillan, Kyle L.</creatorcontrib><creatorcontrib>McNitt‐Gray, Michael F.</creatorcontrib><creatorcontrib>Rogers, D. W. O.</creatorcontrib><creatorcontrib>Samei, Ehsan</creatorcontrib><creatorcontrib>Turner, Adam C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sechopoulos, Ioannis</au><au>Ali, Elsayed S. M.</au><au>Badal, Andreu</au><au>Badano, Aldo</au><au>Boone, John M.</au><au>Kyprianou, Iacovos S.</au><au>Mainegra‐Hing, Ernesto</au><au>McMillan, Kyle L.</au><au>McNitt‐Gray, Michael F.</au><au>Rogers, D. W. O.</au><au>Samei, Ehsan</au><au>Turner, Adam C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2015-10</date><risdate>2015</risdate><volume>42</volume><issue>10</issue><spage>5679</spage><epage>5691</epage><pages>5679-5691</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><abstract>The use of Monte Carlo simulations in diagnostic medical imaging research is widespread due to its flexibility and ability to estimate quantities that are challenging to measure empirically. However, any new Monte Carlo simulation code needs to be validated before it can be used reliably. The type and degree of validation required depends on the goals of the research project, but, typically, such validation involves either comparison of simulation results to physical measurements or to previously published results obtained with established Monte Carlo codes. The former is complicated due to nuances of experimental conditions and uncertainty, while the latter is challenging due to typical graphical presentation and lack of simulation details in previous publications. In addition, entering the field of Monte Carlo simulations in general involves a steep learning curve. It is not a simple task to learn how to program and interpret a Monte Carlo simulation, even when using one of the publicly available code packages. This Task Group report provides a common reference for benchmarking Monte Carlo simulations across a range of Monte Carlo codes and simulation scenarios. In the report, all simulation conditions are provided for six different Monte Carlo simulation cases that involve common x‐ray based imaging research areas. The results obtained for the six cases using four publicly available Monte Carlo software packages are included in tabular form. In addition to a full description of all simulation conditions and results, a discussion and comparison of results among the Monte Carlo packages and the lessons learned during the compilation of these results are included. This abridged version of the report includes only an introductory description of the six cases and a brief example of the results of one of the cases. This work provides an investigator the necessary information to benchmark his/her Monte Carlo simulation software against the reference cases included here before performing his/her own novel research. In addition, an investigator entering the field of Monte Carlo simulations can use these descriptions and results as a self‐teaching tool to ensure that he/she is able to perform a specific simulation correctly. Finally, educators can assign these cases as learning projects as part of course objectives or training programs.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>26429242</pmid><doi>10.1118/1.4928676</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3712-6670</orcidid><orcidid>https://orcid.org/0000000337126670</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0094-2405 |
ispartof | Medical physics (Lancaster), 2015-10, Vol.42 (10), p.5679-5691 |
issn | 0094-2405 2473-4209 |
language | eng |
recordid | cdi_osti_scitechconnect_1401394 |
source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
subjects | Benchmarking Biological material, e.g. blood, urine Haemocytometers Breast Computed tomography Computerised tomographs computerised tomography diagnostic imaging diagnostic radiography Digital computing or data processing equipment or methods, specially adapted for specific applications Digital tomosynthesis mammography EGSnrc geant4 Humans mammography mcnp medical computing Medical X‐ray imaging Monte Carlo Method Monte Carlo methods Monte Carlo simulation Monte Carlo simulations penelope Photons Radiography Reference Standards Research Report test cases Tomography, X-Ray Computed X‐ray imaging X‐ray scattering X‐ray spectra x‐rays |
title | Monte Carlo reference data sets for imaging research: Executive summary of the report of AAPM Research Committee Task Group 195 |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-31T00%3A14%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Monte%20Carlo%20reference%20data%20sets%20for%20imaging%20research:%20Executive%20summary%20of%20the%20report%20of%20AAPM%20Research%20Committee%20Task%20Group%20195&rft.jtitle=Medical%20physics%20(Lancaster)&rft.au=Sechopoulos,%20Ioannis&rft.date=2015-10&rft.volume=42&rft.issue=10&rft.spage=5679&rft.epage=5691&rft.pages=5679-5691&rft.issn=0094-2405&rft.eissn=2473-4209&rft_id=info:doi/10.1118/1.4928676&rft_dat=%3Cproquest_osti_%3E1718910067%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1718910067&rft_id=info:pmid/26429242&rfr_iscdi=true |