The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure

The Baeyer-Villiger monooxygenases (BMVOs) are a group of microbial enzymes that have garnered interest as industrial biocatalysts. While great strides have been made in recent years to understand the mechanism of these enzymes from a structural perspective, our understanding remains incomplete. In...

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Veröffentlicht in:	Biochimica et biophysica acta 2016-12, Vol.1864 (12), p.1641-1648
Hauptverfasser:	Yachnin, Brahm J., Lau, Peter C.K., Berghuis, Albert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter - enzymology Acinetobacter - genetics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Baeyer-Villiger monooxygenase Biocatalysis Calorimetry Catalytic Domain - genetics Crystallography, X-Ray Enzyme catalysis Enzyme mechanism Enzyme Stability Isothermal titration calorimetry (ITC) Kinetics Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Models, Molecular Mutagenesis, Site-Directed NADP - metabolism Oxygenases - chemistry Oxygenases - genetics Oxygenases - metabolism Protein Conformation Protein flexibility Rhodococcus - enzymology Rhodococcus - genetics Scattering, Small Angle Small-angle X-ray scattering (SAXS) X-Ray Diffraction
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