177 Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice

Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate cancer and various non-prostatic tumors that are characterized by PSMA expression on their neovasculature. One of the challenges for small-molecu...

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Veröffentlicht in:	Theranostics 2017, Vol.7 (7), p.1928-1939
Hauptverfasser:	Choy, Cindy J, Ling, Xiaoxi, Geruntho, Jonathan J, Beyer, Sophia K, Latoche, Joseph D, Langton-Webster, Beatrice, Anderson, Carolyn J, Berkman, Clifford E
Format:	Artikel
Sprache:	eng
Schlagworte:	177Lu 60 APPLIED LIFE SCIENCES albumin Albumins - metabolism Amides - administration & dosage Amides - pharmacokinetics Amides - pharmacology Animals Antigens, Surface Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Cell Line, Tumor Disease Models, Animal Glutamate Carboxypeptidase II - antagonists & inhibitors Heterografts Humans Lutetium - administration & dosage Lutetium - pharmacokinetics Lutetium - pharmacology Male Mice Mice, Nude phosphoramidate Phosphoric Acids - administration & dosage Phosphoric Acids - pharmacokinetics Phosphoric Acids - pharmacology Prostatic Neoplasms - drug therapy PSMA Radioisotopes - administration & dosage Radioisotopes - pharmacokinetics Radioisotopes - pharmacology radiotherapy Treatment Outcome
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