Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory subunits, each present in multiple forms, AMPK is best described as a family of related enzymes. In recent years, AMPK has emerged as a desir...

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Veröffentlicht in:	Structure (London) 2014-08, Vol.22 (8), p.1161-1172
Hauptverfasser:	Calabrese, Matthew F., Rajamohan, Francis, Harris, Melissa S., Caspers, Nicole L., Magyar, Rachelle, Withka, Jane M., Wang, Hong, Borzilleri, Kris A., Sahasrabudhe, Parag V., Hoth, Lise R., Geoghegan, Kieran F., Han, Seungil, Brown, Janice, Subashi, Timothy A., Reyes, Allan R., Frisbie, Richard K., Ward, Jessica, Miller, Russell A., Landro, James A., Londregan, Allyn T., Carpino, Philip A., Cabral, Shawn, Smith, Aaron C., Conn, Edward L., Cameron, Kimberly O., Qiu, Xiayang, Kurumbail, Ravi G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Monophosphate - metabolism Allosteric Site - genetics AMP-Activated Protein Kinases - chemistry AMP-Activated Protein Kinases - metabolism AMP-Activated Protein Kinases - physiology Binding Cellular Diseases Drug Delivery Systems Enzyme Activation - physiology Enzymes Humans Kinases Kinetics Ligands Models, Molecular Modulation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phosphorylation Protein Conformation Protein Isoforms - chemistry Protein Isoforms - metabolism Protein Isoforms - physiology Pyrones - metabolism Structure-Activity Relationship Surface Plasmon Resonance Thiophenes - metabolism
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