Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation

Abstract Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, significant relapse and progression rates as...

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Veröffentlicht in:	Drug resistance updates 2016-01, Vol.24 (C), p.34-54
Hauptverfasser:	Ferreira, José Alexandre, Peixoto, Andreia, Neves, Manuel, Gaiteiro, Cristiana, Reis, Celso A, Assaraf, Yehuda G, Santos, Lúcio Lara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Biomarkers, Tumor - metabolism Cancer biomarkers Cancer stem cells Cancer therapy Chemotherapy resistance Cisplatin Cisplatin - pharmacology Drug Resistance, Neoplasm - physiology Epithelial-to-mesenchymal Glycosylation - drug effects Hematology, Oncology and Palliative Medicine Humans Infectious Disease Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Protein glycosylation
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