Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers
The authors report on series of side‐chain smectic liquid crystal elastomer (LCE) cell scaffolds based on star block‐copolymers featuring 3‐arm, 4‐arm, and 6‐arm central nodes. A particular focus of these studies is placed on the mechanical properties of these LCEs and their impact on cell response....
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| Veröffentlicht in: | Macromolecular bioscience 2017-02, Vol.17 (2), p.1600278-n/a |
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| creator | Sharma, Anshul Mori, Taizo Mahnen, Cory J. Everson, Heather R. Leslie, Michelle T. Nielsen, Alek d. Lussier, Laurent Zhu, Chenhui Malcuit, Christopher Hegmann, Torsten McDonough, Jennifer A. Freeman, Ernest J. Korley, LaShanda T. J. Clements, Robert J. Hegmann, Elda |
| description | The authors report on series of side‐chain smectic liquid crystal elastomer (LCE) cell scaffolds based on star block‐copolymers featuring 3‐arm, 4‐arm, and 6‐arm central nodes. A particular focus of these studies is placed on the mechanical properties of these LCEs and their impact on cell response. The introduction of diverse central nodes allows to alter and custom‐modify the mechanical properties of LCE scaffolds to values on the same order of magnitude of various tissues of interest. In addition, it is continued to vary the position of the LC pendant group. The central node and the position of cholesterol pendants in the backbone of ε‐CL blocks (alpha and gamma series) affect the mechanical properties as well as cell proliferation and particularly cell alignment. Cell directionality tests are presented demonstrating that several LCE scaffolds show cell attachment, proliferation, narrow orientational dispersion of cells, and highly anisotropic cell growth on the as‐synthesized LCE materials.
Biocompatible and biodegradable liquid crystal elastomers are investigated as spatial cell scaffolds, promoting cell attachment, proliferation, and highly anisotropic cell growth. Tuning the mechanical properties allows the creation of 3D cell cultures for a wide range of cell lines related to various tissues. |
| doi_str_mv | 10.1002/mabi.201600278 |
| format | Article |
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Biocompatible and biodegradable liquid crystal elastomers are investigated as spatial cell scaffolds, promoting cell attachment, proliferation, and highly anisotropic cell growth. Tuning the mechanical properties allows the creation of 3D cell cultures for a wide range of cell lines related to various tissues.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201600278</identifier><identifier>PMID: 27805765</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>3D porous scaffolds ; Animals ; Biocompatibility ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biodegradability ; Block copolymers ; Cell adhesion ; cell alignment ; cell directionality ; Cell growth ; Cell Line ; Cell Movement - drug effects ; Cell proliferation ; Cell Proliferation - drug effects ; Cellular structure ; Cholesterol ; Copolymers ; Dermis - cytology ; Elastomers ; Elastomers - chemical synthesis ; Elastomers - chemistry ; Elastomers - pharmacology ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Humans ; liquid crystal elastomers ; Liquid Crystals - chemistry ; Liquid Crystals - ultrastructure ; Mechanical Phenomena ; Mechanical properties ; mechanics ; Mice ; Microscopy, Polarization ; Myoblasts - cytology ; Myoblasts - drug effects ; Nodes ; Porosity ; Scaffolds ; Scattering, Small Angle ; Smectic liquid crystals ; Stress, Mechanical ; Temperature ; X-Ray Diffraction</subject><ispartof>Macromolecular bioscience, 2017-02, Vol.17 (2), p.1600278-n/a</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5678-b6b7441f7bb6d1eaa43f0966b630f033d4d2dd0216477b7b16288eb5bc513a5d3</citedby><cites>FETCH-LOGICAL-c5678-b6b7441f7bb6d1eaa43f0966b630f033d4d2dd0216477b7b16288eb5bc513a5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.201600278$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.201600278$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27913,27914,45563,45564</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27805765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1356406$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Anshul</creatorcontrib><creatorcontrib>Mori, Taizo</creatorcontrib><creatorcontrib>Mahnen, Cory J.</creatorcontrib><creatorcontrib>Everson, Heather R.</creatorcontrib><creatorcontrib>Leslie, Michelle T.</creatorcontrib><creatorcontrib>Nielsen, Alek d.</creatorcontrib><creatorcontrib>Lussier, Laurent</creatorcontrib><creatorcontrib>Zhu, Chenhui</creatorcontrib><creatorcontrib>Malcuit, Christopher</creatorcontrib><creatorcontrib>Hegmann, Torsten</creatorcontrib><creatorcontrib>McDonough, Jennifer A.</creatorcontrib><creatorcontrib>Freeman, Ernest J.</creatorcontrib><creatorcontrib>Korley, LaShanda T. J.</creatorcontrib><creatorcontrib>Clements, Robert J.</creatorcontrib><creatorcontrib>Hegmann, Elda</creatorcontrib><creatorcontrib>Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)</creatorcontrib><title>Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>The authors report on series of side‐chain smectic liquid crystal elastomer (LCE) cell scaffolds based on star block‐copolymers featuring 3‐arm, 4‐arm, and 6‐arm central nodes. A particular focus of these studies is placed on the mechanical properties of these LCEs and their impact on cell response. The introduction of diverse central nodes allows to alter and custom‐modify the mechanical properties of LCE scaffolds to values on the same order of magnitude of various tissues of interest. In addition, it is continued to vary the position of the LC pendant group. The central node and the position of cholesterol pendants in the backbone of ε‐CL blocks (alpha and gamma series) affect the mechanical properties as well as cell proliferation and particularly cell alignment. Cell directionality tests are presented demonstrating that several LCE scaffolds show cell attachment, proliferation, narrow orientational dispersion of cells, and highly anisotropic cell growth on the as‐synthesized LCE materials.
Biocompatible and biodegradable liquid crystal elastomers are investigated as spatial cell scaffolds, promoting cell attachment, proliferation, and highly anisotropic cell growth. Tuning the mechanical properties allows the creation of 3D cell cultures for a wide range of cell lines related to various tissues.</description><subject>3D porous scaffolds</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biodegradability</subject><subject>Block copolymers</subject><subject>Cell adhesion</subject><subject>cell alignment</subject><subject>cell directionality</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell Movement - drug effects</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cellular structure</subject><subject>Cholesterol</subject><subject>Copolymers</subject><subject>Dermis - cytology</subject><subject>Elastomers</subject><subject>Elastomers - chemical synthesis</subject><subject>Elastomers - chemistry</subject><subject>Elastomers - pharmacology</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Humans</subject><subject>liquid crystal elastomers</subject><subject>Liquid Crystals - chemistry</subject><subject>Liquid Crystals - ultrastructure</subject><subject>Mechanical Phenomena</subject><subject>Mechanical properties</subject><subject>mechanics</subject><subject>Mice</subject><subject>Microscopy, Polarization</subject><subject>Myoblasts - cytology</subject><subject>Myoblasts - drug effects</subject><subject>Nodes</subject><subject>Porosity</subject><subject>Scaffolds</subject><subject>Scattering, Small Angle</subject><subject>Smectic liquid crystals</subject><subject>Stress, Mechanical</subject><subject>Temperature</subject><subject>X-Ray Diffraction</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktvEzEUhUcIREtgyxJZsGFBgu3xY2bZRgEqpaKiwNbya6irmXFqe4Tyc_pPe9OUILEAVva1v3uuj3Wq6iXBC4IxfT9oExYUEwGFbB5Vx0QQMeek5Y8P-0YeVc9yvsaYyKalT6sjQDGXgh9Xt6uu87ZkFDt0WdJky5R0j77rFHQJcYSLEZUrj5a-76deJ_TF5w2ce6RHh869vdJjsNBykeLGpxL8vdZpiDYOG9AwvX-3K53_kbTT9-Wu9SKmOGV0OcD4YNE63EzBoWXa5gJqq17nEgef8vPqSaf77F88rLPq24fV1-Wn-frzx7PlyXpuuZDN3AgjGSOdNEY44rVmdYdbIYyocYfr2jFHncOUCCalkYYI2jTecGM5qTV39ax6vdeNuQSVbSjgzcZxhPcpUnPBsADo7R7apHgz-VzUELKFr9GjBzcK_po2NWsl_Q-05pwyTDigb_5Ar-OURnALFHhoWUPZ3ynRwFwCPmfVYk_ZFHNOvlObFAadtopgtYuM2kVGHSIDDa8eZCczeHfAf2UEgHYP_Ay93_5DTp2fnJ79Fr8DNQDNKg</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Sharma, Anshul</creator><creator>Mori, Taizo</creator><creator>Mahnen, Cory J.</creator><creator>Everson, Heather R.</creator><creator>Leslie, Michelle T.</creator><creator>Nielsen, Alek d.</creator><creator>Lussier, Laurent</creator><creator>Zhu, Chenhui</creator><creator>Malcuit, Christopher</creator><creator>Hegmann, Torsten</creator><creator>McDonough, Jennifer A.</creator><creator>Freeman, Ernest J.</creator><creator>Korley, LaShanda T. J.</creator><creator>Clements, Robert J.</creator><creator>Hegmann, Elda</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201702</creationdate><title>Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers</title><author>Sharma, Anshul ; Mori, Taizo ; Mahnen, Cory J. ; Everson, Heather R. ; Leslie, Michelle T. ; Nielsen, Alek d. ; Lussier, Laurent ; Zhu, Chenhui ; Malcuit, Christopher ; Hegmann, Torsten ; McDonough, Jennifer A. ; Freeman, Ernest J. ; Korley, LaShanda T. 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J.</creatorcontrib><creatorcontrib>Clements, Robert J.</creatorcontrib><creatorcontrib>Hegmann, Elda</creatorcontrib><creatorcontrib>Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Anshul</au><au>Mori, Taizo</au><au>Mahnen, Cory J.</au><au>Everson, Heather R.</au><au>Leslie, Michelle T.</au><au>Nielsen, Alek d.</au><au>Lussier, Laurent</au><au>Zhu, Chenhui</au><au>Malcuit, Christopher</au><au>Hegmann, Torsten</au><au>McDonough, Jennifer A.</au><au>Freeman, Ernest J.</au><au>Korley, LaShanda T. J.</au><au>Clements, Robert J.</au><au>Hegmann, Elda</au><aucorp>Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2017-02</date><risdate>2017</risdate><volume>17</volume><issue>2</issue><spage>1600278</spage><epage>n/a</epage><pages>1600278-n/a</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>The authors report on series of side‐chain smectic liquid crystal elastomer (LCE) cell scaffolds based on star block‐copolymers featuring 3‐arm, 4‐arm, and 6‐arm central nodes. A particular focus of these studies is placed on the mechanical properties of these LCEs and their impact on cell response. The introduction of diverse central nodes allows to alter and custom‐modify the mechanical properties of LCE scaffolds to values on the same order of magnitude of various tissues of interest. In addition, it is continued to vary the position of the LC pendant group. The central node and the position of cholesterol pendants in the backbone of ε‐CL blocks (alpha and gamma series) affect the mechanical properties as well as cell proliferation and particularly cell alignment. Cell directionality tests are presented demonstrating that several LCE scaffolds show cell attachment, proliferation, narrow orientational dispersion of cells, and highly anisotropic cell growth on the as‐synthesized LCE materials.
Biocompatible and biodegradable liquid crystal elastomers are investigated as spatial cell scaffolds, promoting cell attachment, proliferation, and highly anisotropic cell growth. Tuning the mechanical properties allows the creation of 3D cell cultures for a wide range of cell lines related to various tissues.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27805765</pmid><doi>10.1002/mabi.201600278</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Macromolecular bioscience, 2017-02, Vol.17 (2), p.1600278-n/a |
| issn | 1616-5187 1616-5195 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 3D porous scaffolds Animals Biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biodegradability Block copolymers Cell adhesion cell alignment cell directionality Cell growth Cell Line Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cellular structure Cholesterol Copolymers Dermis - cytology Elastomers Elastomers - chemical synthesis Elastomers - chemistry Elastomers - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Humans liquid crystal elastomers Liquid Crystals - chemistry Liquid Crystals - ultrastructure Mechanical Phenomena Mechanical properties mechanics Mice Microscopy, Polarization Myoblasts - cytology Myoblasts - drug effects Nodes Porosity Scaffolds Scattering, Small Angle Smectic liquid crystals Stress, Mechanical Temperature X-Ray Diffraction |
| title | Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers |
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