Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging
Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and wit...
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Veröffentlicht in: | Analyst (London) 2015-06, Vol.14 (11), p.3731-3737 |
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creator | Ho, I-Ting Sessler, Jonathan L Gambhir, Sanjiv Sam Jokerst, Jesse V |
description | Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity
via
photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-
co
-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM)
in vitro
and 0.57 ppm (19 fCi; 0.52 μM)
in vivo
. To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation
via
photoacoustic imaging.
Chemical tools that can report radioactive isotopes would be of interest to the defense community. |
doi_str_mv | 10.1039/c5an00207a |
format | Article |
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via
photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-
co
-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM)
in vitro
and 0.57 ppm (19 fCi; 0.52 μM)
in vivo
. To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation
via
photoacoustic imaging.
Chemical tools that can report radioactive isotopes would be of interest to the defense community.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c5an00207a</identifier><identifier>PMID: 25854506</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>activable nanoparticle ; Animals ; Biomedical materials ; Cations ; dosimetery ; Female ; Imaging ; In vivo testing ; In vivo tests ; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY ; Lactic Acid - chemistry ; Limit of Detection ; MATERIALS SCIENCE ; Mice ; Molecular Imaging ; Nanoparticles ; Nanoparticles - chemistry ; Nanostructure ; Particle Size ; photoacoustic imaging ; Photoacoustic Techniques - methods ; Polyglycolic Acid - chemistry ; porphyrinoid macrocycles ; Porphyrins - chemistry ; Uranium ; Uranium - analysis ; Uranium - chemistry</subject><ispartof>Analyst (London), 2015-06, Vol.14 (11), p.3731-3737</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-f792e2e65486856443d84b978277f13e7a0cbaa52aad755f4935698ff9502dd83</citedby><cites>FETCH-LOGICAL-c431t-f792e2e65486856443d84b978277f13e7a0cbaa52aad755f4935698ff9502dd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2829,2830,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25854506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1346160$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, I-Ting</creatorcontrib><creatorcontrib>Sessler, Jonathan L</creatorcontrib><creatorcontrib>Gambhir, Sanjiv Sam</creatorcontrib><creatorcontrib>Jokerst, Jesse V</creatorcontrib><creatorcontrib>Univ. of Texas, Austin, TX (United States)</creatorcontrib><title>Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity
via
photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-
co
-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM)
in vitro
and 0.57 ppm (19 fCi; 0.52 μM)
in vivo
. To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation
via
photoacoustic imaging.
Chemical tools that can report radioactive isotopes would be of interest to the defense community.</description><subject>activable nanoparticle</subject><subject>Animals</subject><subject>Biomedical materials</subject><subject>Cations</subject><subject>dosimetery</subject><subject>Female</subject><subject>Imaging</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY</subject><subject>Lactic Acid - chemistry</subject><subject>Limit of Detection</subject><subject>MATERIALS SCIENCE</subject><subject>Mice</subject><subject>Molecular Imaging</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructure</subject><subject>Particle Size</subject><subject>photoacoustic imaging</subject><subject>Photoacoustic Techniques - methods</subject><subject>Polyglycolic Acid - chemistry</subject><subject>porphyrinoid macrocycles</subject><subject>Porphyrins - chemistry</subject><subject>Uranium</subject><subject>Uranium - analysis</subject><subject>Uranium - chemistry</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTtvFDEUhS1ERJaQhh5kqFCkIX7PTLla8YgUBQpSW3f9yBrN2oPtCcq_x8mG0FHZ1vl0fM69CL2m5CMlfDw3EiIhjPTwDK0oV6KTkg3P0YoQwjumpDhGL0v52Z6USPICHTM5SCGJWqH6HXIteHYZb8M0hRSxddWZen9LHi8ZYlj2-HeoOwx4Tnne3eUQU7CdSbFCiCHe4Agxzc0pmMlhiBaHiG_DbcLzLtUEJi2laTjs4abhr9CRh6m408fzBF1__vRj87W7_PblYrO-7IzgtHa-H5ljruUf1CCVENwOYjv2A-t7T7nrgZgtgGQAtpfSi5FLNQ7ej5Iwawd-gt4ffFP7XRcTWrFdSx1bP025UFSRBn04QHNOvxZXqt6HYtw0QXQttqZqZJxSIXlDzw6oyamU7Lyec6uU7zQl-n4VeiPXVw-rWDf47aPvst07-4T-nX0D3hyAXMyT-m-XTX_3P13P1vM_-KGZ_Q</recordid><startdate>20150607</startdate><enddate>20150607</enddate><creator>Ho, I-Ting</creator><creator>Sessler, Jonathan L</creator><creator>Gambhir, Sanjiv Sam</creator><creator>Jokerst, Jesse V</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>OIOZB</scope><scope>OTOTI</scope></search><sort><creationdate>20150607</creationdate><title>Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging</title><author>Ho, I-Ting ; Sessler, Jonathan L ; Gambhir, Sanjiv Sam ; Jokerst, Jesse V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-f792e2e65486856443d84b978277f13e7a0cbaa52aad755f4935698ff9502dd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>activable nanoparticle</topic><topic>Animals</topic><topic>Biomedical materials</topic><topic>Cations</topic><topic>dosimetery</topic><topic>Female</topic><topic>Imaging</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY</topic><topic>Lactic Acid - chemistry</topic><topic>Limit of Detection</topic><topic>MATERIALS SCIENCE</topic><topic>Mice</topic><topic>Molecular Imaging</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanostructure</topic><topic>Particle Size</topic><topic>photoacoustic imaging</topic><topic>Photoacoustic Techniques - methods</topic><topic>Polyglycolic Acid - chemistry</topic><topic>porphyrinoid macrocycles</topic><topic>Porphyrins - chemistry</topic><topic>Uranium</topic><topic>Uranium - analysis</topic><topic>Uranium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, I-Ting</creatorcontrib><creatorcontrib>Sessler, Jonathan L</creatorcontrib><creatorcontrib>Gambhir, Sanjiv Sam</creatorcontrib><creatorcontrib>Jokerst, Jesse V</creatorcontrib><creatorcontrib>Univ. of Texas, Austin, TX (United States)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, I-Ting</au><au>Sessler, Jonathan L</au><au>Gambhir, Sanjiv Sam</au><au>Jokerst, Jesse V</au><aucorp>Univ. of Texas, Austin, TX (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2015-06-07</date><risdate>2015</risdate><volume>14</volume><issue>11</issue><spage>3731</spage><epage>3737</epage><pages>3731-3737</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><abstract>Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity
via
photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-
co
-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM)
in vitro
and 0.57 ppm (19 fCi; 0.52 μM)
in vivo
. To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation
via
photoacoustic imaging.
Chemical tools that can report radioactive isotopes would be of interest to the defense community.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>25854506</pmid><doi>10.1039/c5an00207a</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | activable nanoparticle Animals Biomedical materials Cations dosimetery Female Imaging In vivo testing In vivo tests INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY Lactic Acid - chemistry Limit of Detection MATERIALS SCIENCE Mice Molecular Imaging Nanoparticles Nanoparticles - chemistry Nanostructure Particle Size photoacoustic imaging Photoacoustic Techniques - methods Polyglycolic Acid - chemistry porphyrinoid macrocycles Porphyrins - chemistry Uranium Uranium - analysis Uranium - chemistry |
title | Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging |
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