Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging

Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and wit...

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Veröffentlicht in:Analyst (London) 2015-06, Vol.14 (11), p.3731-3737
Hauptverfasser: Ho, I-Ting, Sessler, Jonathan L, Gambhir, Sanjiv Sam, Jokerst, Jesse V
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container_issue 11
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container_title Analyst (London)
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creator Ho, I-Ting
Sessler, Jonathan L
Gambhir, Sanjiv Sam
Jokerst, Jesse V
description Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report ∼250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity via photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic- co -glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) in vitro and 0.57 ppm (19 fCi; 0.52 μM) in vivo . To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging. Chemical tools that can report radioactive isotopes would be of interest to the defense community.
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source MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects activable nanoparticle
Animals
Biomedical materials
Cations
dosimetery
Female
Imaging
In vivo testing
In vivo tests
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Lactic Acid - chemistry
Limit of Detection
MATERIALS SCIENCE
Mice
Molecular Imaging
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Particle Size
photoacoustic imaging
Photoacoustic Techniques - methods
Polyglycolic Acid - chemistry
porphyrinoid macrocycles
Porphyrins - chemistry
Uranium
Uranium - analysis
Uranium - chemistry
title Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging
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