A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)

The majority of structural damage and loss of life during a hurricane is due to storm surge, thus it is important for communities in hurricane-prone regions to understand their risk due to surge. Storm surge in particular is largely influenced by coastal features such as topography/bathymetry and bo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Monthly weather review 2017-03, Vol.145 (3), p.929-954
Hauptverfasser: Graham, Lindley, Butler, Troy, Walsh, Scott, Dawson, Clint, Westerink, Joannes J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 954
container_issue 3
container_start_page 929
container_title Monthly weather review
container_volume 145
creator Graham, Lindley
Butler, Troy
Walsh, Scott
Dawson, Clint
Westerink, Joannes J.
description The majority of structural damage and loss of life during a hurricane is due to storm surge, thus it is important for communities in hurricane-prone regions to understand their risk due to surge. Storm surge in particular is largely influenced by coastal features such as topography/bathymetry and bottom roughness. Bottom roughness determines how much resistance there is to the flow. Manning’s formula can be used to model the bottom stress with the Manning’s n coefficient, a spatially dependent field. Given a storm surge model and a set of model outputs, an inverse problem may be solved to determine probable Manning’s n fields to use for predictive simulations. The inverse problem is formulated and solved in a measure-theoretic framework using the state-of-the-art Advanced Circulation (ADCIRC) storm surge model. The use of measure theory requires minimal assumptions and involves the direct inversion of the physics-based map from model inputs to output data determined by the ADCIRC model. Thus, key geometric relationships in this map are preserved and exploited. By using a recently available subdomain implementation of ADCIRC that significantly reduces the computational cost of forward model solves, the authors demonstrate the method on a case study using data obtained from an ADCIRC hindcast study of Hurricane Gustav (2008) to quantify uncertainties in Manning’s n within Bay St. Louis. However, the methodology is general and could be applied to any inverse problem that involves a map from model input to output quantities of interest.
doi_str_mv 10.1175/MWR-D-16-0149.1
format Article
fullrecord <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_1344323</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1924619602</sourcerecordid><originalsourceid>FETCH-LOGICAL-c296t-b71d89e173103ea4550a5670a15c2bf79150f08705b5fdee390294735eb90d453</originalsourceid><addsrcrecordid>eNotkU1vEzEQhi0EEqFw5jqCCxycjj835pamn1IqJCjiaDleb-MqWbe2Fym_gT-No3AajfTMo5l5CfnIcM5Yp87vf_-gl5RpikyaOXtFZkxxpCiNeE1miLyjqKV8S96V8oSIWks-I3-XcB9cmXKgD9uQcqjRw3L3mHKs2z0MKcNVqXHvahwf4SLVmvZwnaOvMY0QR3CwSq5Ut4O7cRfqN1i5EuBnnfoDpAEu3KE1c1inKRbop3zU3E65GdwY4GZqo3_gC0dcfH1P3gxuV8KH__WM_Lq-eljd0vX3m7vVck09N7rSTcf6hQmsEwxFcFIpdEp36JjyfDN0hikccNGh2qihD0EY5EZ2QoWNwV4qcUY-nbypXWaLjzX4rU_jGHy1TEgpuGjQ5xP0nNPLFEq1T2nKY9vLMsOlZkYjb9T5ifI5lZLDYJ9ze1Y-WIb2GIttsdhLy7Q9xtLs_wDqrn3U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1924619602</pqid></control><display><type>article</type><title>A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)</title><source>American Meteorological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Graham, Lindley ; Butler, Troy ; Walsh, Scott ; Dawson, Clint ; Westerink, Joannes J.</creator><creatorcontrib>Graham, Lindley ; Butler, Troy ; Walsh, Scott ; Dawson, Clint ; Westerink, Joannes J. ; Univ. of Texas, Austin, TX (United States) ; Florida State Univ., Tallahassee, FL (United States) ; Colorado State Univ., Fort Collins, CO (United States)</creatorcontrib><description>The majority of structural damage and loss of life during a hurricane is due to storm surge, thus it is important for communities in hurricane-prone regions to understand their risk due to surge. Storm surge in particular is largely influenced by coastal features such as topography/bathymetry and bottom roughness. Bottom roughness determines how much resistance there is to the flow. Manning’s formula can be used to model the bottom stress with the Manning’s n coefficient, a spatially dependent field. Given a storm surge model and a set of model outputs, an inverse problem may be solved to determine probable Manning’s n fields to use for predictive simulations. The inverse problem is formulated and solved in a measure-theoretic framework using the state-of-the-art Advanced Circulation (ADCIRC) storm surge model. The use of measure theory requires minimal assumptions and involves the direct inversion of the physics-based map from model inputs to output data determined by the ADCIRC model. Thus, key geometric relationships in this map are preserved and exploited. By using a recently available subdomain implementation of ADCIRC that significantly reduces the computational cost of forward model solves, the authors demonstrate the method on a case study using data obtained from an ADCIRC hindcast study of Hurricane Gustav (2008) to quantify uncertainties in Manning’s n within Bay St. Louis. However, the methodology is general and could be applied to any inverse problem that involves a map from model input to output quantities of interest.</description><identifier>ISSN: 0027-0644</identifier><identifier>EISSN: 1520-0493</identifier><identifier>DOI: 10.1175/MWR-D-16-0149.1</identifier><language>eng</language><publisher>Washington: American Meteorological Society</publisher><subject>Banks (topography) ; Bathymetry ; Bed roughness ; Bottom friction ; Bottom roughness ; Bottom stress ; Boundary conditions ; Case studies ; Circulation ; Coastal inlets ; Computational efficiency ; Computer applications ; Computer simulation ; Cost engineering ; ENVIRONMENTAL SCIENCES ; Exploitation ; Frameworks ; Friction ; Hurricanes ; Inlets (waterways) ; Inverse methods ; Inverse problems ; Mathematical models ; Numerical weather prediction/forecasting ; Physics ; Roughness ; Sensitivity analysis ; Slope ; Statistical forecasting ; Statistical techniques ; Storm damage ; Storm surges ; Storms ; Structural damage ; Tidal waves ; Topography ; Topography (geology) ; Vegetation</subject><ispartof>Monthly weather review, 2017-03, Vol.145 (3), p.929-954</ispartof><rights>Copyright American Meteorological Society Mar 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296t-b71d89e173103ea4550a5670a15c2bf79150f08705b5fdee390294735eb90d453</citedby><cites>FETCH-LOGICAL-c296t-b71d89e173103ea4550a5670a15c2bf79150f08705b5fdee390294735eb90d453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3681,27924,27925</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/1344323$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Graham, Lindley</creatorcontrib><creatorcontrib>Butler, Troy</creatorcontrib><creatorcontrib>Walsh, Scott</creatorcontrib><creatorcontrib>Dawson, Clint</creatorcontrib><creatorcontrib>Westerink, Joannes J.</creatorcontrib><creatorcontrib>Univ. of Texas, Austin, TX (United States)</creatorcontrib><creatorcontrib>Florida State Univ., Tallahassee, FL (United States)</creatorcontrib><creatorcontrib>Colorado State Univ., Fort Collins, CO (United States)</creatorcontrib><title>A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)</title><title>Monthly weather review</title><description>The majority of structural damage and loss of life during a hurricane is due to storm surge, thus it is important for communities in hurricane-prone regions to understand their risk due to surge. Storm surge in particular is largely influenced by coastal features such as topography/bathymetry and bottom roughness. Bottom roughness determines how much resistance there is to the flow. Manning’s formula can be used to model the bottom stress with the Manning’s n coefficient, a spatially dependent field. Given a storm surge model and a set of model outputs, an inverse problem may be solved to determine probable Manning’s n fields to use for predictive simulations. The inverse problem is formulated and solved in a measure-theoretic framework using the state-of-the-art Advanced Circulation (ADCIRC) storm surge model. The use of measure theory requires minimal assumptions and involves the direct inversion of the physics-based map from model inputs to output data determined by the ADCIRC model. Thus, key geometric relationships in this map are preserved and exploited. By using a recently available subdomain implementation of ADCIRC that significantly reduces the computational cost of forward model solves, the authors demonstrate the method on a case study using data obtained from an ADCIRC hindcast study of Hurricane Gustav (2008) to quantify uncertainties in Manning’s n within Bay St. Louis. However, the methodology is general and could be applied to any inverse problem that involves a map from model input to output quantities of interest.</description><subject>Banks (topography)</subject><subject>Bathymetry</subject><subject>Bed roughness</subject><subject>Bottom friction</subject><subject>Bottom roughness</subject><subject>Bottom stress</subject><subject>Boundary conditions</subject><subject>Case studies</subject><subject>Circulation</subject><subject>Coastal inlets</subject><subject>Computational efficiency</subject><subject>Computer applications</subject><subject>Computer simulation</subject><subject>Cost engineering</subject><subject>ENVIRONMENTAL SCIENCES</subject><subject>Exploitation</subject><subject>Frameworks</subject><subject>Friction</subject><subject>Hurricanes</subject><subject>Inlets (waterways)</subject><subject>Inverse methods</subject><subject>Inverse problems</subject><subject>Mathematical models</subject><subject>Numerical weather prediction/forecasting</subject><subject>Physics</subject><subject>Roughness</subject><subject>Sensitivity analysis</subject><subject>Slope</subject><subject>Statistical forecasting</subject><subject>Statistical techniques</subject><subject>Storm damage</subject><subject>Storm surges</subject><subject>Storms</subject><subject>Structural damage</subject><subject>Tidal waves</subject><subject>Topography</subject><subject>Topography (geology)</subject><subject>Vegetation</subject><issn>0027-0644</issn><issn>1520-0493</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNotkU1vEzEQhi0EEqFw5jqCCxycjj835pamn1IqJCjiaDleb-MqWbe2Fym_gT-No3AajfTMo5l5CfnIcM5Yp87vf_-gl5RpikyaOXtFZkxxpCiNeE1miLyjqKV8S96V8oSIWks-I3-XcB9cmXKgD9uQcqjRw3L3mHKs2z0MKcNVqXHvahwf4SLVmvZwnaOvMY0QR3CwSq5Ut4O7cRfqN1i5EuBnnfoDpAEu3KE1c1inKRbop3zU3E65GdwY4GZqo3_gC0dcfH1P3gxuV8KH__WM_Lq-eljd0vX3m7vVck09N7rSTcf6hQmsEwxFcFIpdEp36JjyfDN0hikccNGh2qihD0EY5EZ2QoWNwV4qcUY-nbypXWaLjzX4rU_jGHy1TEgpuGjQ5xP0nNPLFEq1T2nKY9vLMsOlZkYjb9T5ifI5lZLDYJ9ze1Y-WIb2GIttsdhLy7Q9xtLs_wDqrn3U</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Graham, Lindley</creator><creator>Butler, Troy</creator><creator>Walsh, Scott</creator><creator>Dawson, Clint</creator><creator>Westerink, Joannes J.</creator><general>American Meteorological Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7TG</scope><scope>7TN</scope><scope>7UA</scope><scope>7XB</scope><scope>88F</scope><scope>88I</scope><scope>8AF</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H96</scope><scope>HCIFZ</scope><scope>KL.</scope><scope>L.G</scope><scope>L7M</scope><scope>M1Q</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>OTOTI</scope></search><sort><creationdate>20170301</creationdate><title>A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)</title><author>Graham, Lindley ; Butler, Troy ; Walsh, Scott ; Dawson, Clint ; Westerink, Joannes J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-b71d89e173103ea4550a5670a15c2bf79150f08705b5fdee390294735eb90d453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Banks (topography)</topic><topic>Bathymetry</topic><topic>Bed roughness</topic><topic>Bottom friction</topic><topic>Bottom roughness</topic><topic>Bottom stress</topic><topic>Boundary conditions</topic><topic>Case studies</topic><topic>Circulation</topic><topic>Coastal inlets</topic><topic>Computational efficiency</topic><topic>Computer applications</topic><topic>Computer simulation</topic><topic>Cost engineering</topic><topic>ENVIRONMENTAL SCIENCES</topic><topic>Exploitation</topic><topic>Frameworks</topic><topic>Friction</topic><topic>Hurricanes</topic><topic>Inlets (waterways)</topic><topic>Inverse methods</topic><topic>Inverse problems</topic><topic>Mathematical models</topic><topic>Numerical weather prediction/forecasting</topic><topic>Physics</topic><topic>Roughness</topic><topic>Sensitivity analysis</topic><topic>Slope</topic><topic>Statistical forecasting</topic><topic>Statistical techniques</topic><topic>Storm damage</topic><topic>Storm surges</topic><topic>Storms</topic><topic>Structural damage</topic><topic>Tidal waves</topic><topic>Topography</topic><topic>Topography (geology)</topic><topic>Vegetation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graham, Lindley</creatorcontrib><creatorcontrib>Butler, Troy</creatorcontrib><creatorcontrib>Walsh, Scott</creatorcontrib><creatorcontrib>Dawson, Clint</creatorcontrib><creatorcontrib>Westerink, Joannes J.</creatorcontrib><creatorcontrib>Univ. of Texas, Austin, TX (United States)</creatorcontrib><creatorcontrib>Florida State Univ., Tallahassee, FL (United States)</creatorcontrib><creatorcontrib>Colorado State Univ., Fort Collins, CO (United States)</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Military Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy &amp; Non-Living Resources</collection><collection>SciTech Premium Collection</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Military Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>OSTI.GOV</collection><jtitle>Monthly weather review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graham, Lindley</au><au>Butler, Troy</au><au>Walsh, Scott</au><au>Dawson, Clint</au><au>Westerink, Joannes J.</au><aucorp>Univ. of Texas, Austin, TX (United States)</aucorp><aucorp>Florida State Univ., Tallahassee, FL (United States)</aucorp><aucorp>Colorado State Univ., Fort Collins, CO (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)</atitle><jtitle>Monthly weather review</jtitle><date>2017-03-01</date><risdate>2017</risdate><volume>145</volume><issue>3</issue><spage>929</spage><epage>954</epage><pages>929-954</pages><issn>0027-0644</issn><eissn>1520-0493</eissn><abstract>The majority of structural damage and loss of life during a hurricane is due to storm surge, thus it is important for communities in hurricane-prone regions to understand their risk due to surge. Storm surge in particular is largely influenced by coastal features such as topography/bathymetry and bottom roughness. Bottom roughness determines how much resistance there is to the flow. Manning’s formula can be used to model the bottom stress with the Manning’s n coefficient, a spatially dependent field. Given a storm surge model and a set of model outputs, an inverse problem may be solved to determine probable Manning’s n fields to use for predictive simulations. The inverse problem is formulated and solved in a measure-theoretic framework using the state-of-the-art Advanced Circulation (ADCIRC) storm surge model. The use of measure theory requires minimal assumptions and involves the direct inversion of the physics-based map from model inputs to output data determined by the ADCIRC model. Thus, key geometric relationships in this map are preserved and exploited. By using a recently available subdomain implementation of ADCIRC that significantly reduces the computational cost of forward model solves, the authors demonstrate the method on a case study using data obtained from an ADCIRC hindcast study of Hurricane Gustav (2008) to quantify uncertainties in Manning’s n within Bay St. Louis. However, the methodology is general and could be applied to any inverse problem that involves a map from model input to output quantities of interest.</abstract><cop>Washington</cop><pub>American Meteorological Society</pub><doi>10.1175/MWR-D-16-0149.1</doi><tpages>26</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0027-0644
ispartof Monthly weather review, 2017-03, Vol.145 (3), p.929-954
issn 0027-0644
1520-0493
language eng
recordid cdi_osti_scitechconnect_1344323
source American Meteorological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Banks (topography)
Bathymetry
Bed roughness
Bottom friction
Bottom roughness
Bottom stress
Boundary conditions
Case studies
Circulation
Coastal inlets
Computational efficiency
Computer applications
Computer simulation
Cost engineering
ENVIRONMENTAL SCIENCES
Exploitation
Frameworks
Friction
Hurricanes
Inlets (waterways)
Inverse methods
Inverse problems
Mathematical models
Numerical weather prediction/forecasting
Physics
Roughness
Sensitivity analysis
Slope
Statistical forecasting
Statistical techniques
Storm damage
Storm surges
Storms
Structural damage
Tidal waves
Topography
Topography (geology)
Vegetation
title A Measure-Theoretic Algorithm for Estimating Bottom Friction in a Coastal Inlet: Case Study of Bay St. Louis during Hurricane Gustav (2008)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T10%3A22%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Measure-Theoretic%20Algorithm%20for%20Estimating%20Bottom%20Friction%20in%20a%20Coastal%20Inlet:%20Case%20Study%20of%20Bay%20St.%20Louis%20during%20Hurricane%20Gustav%20(2008)&rft.jtitle=Monthly%20weather%20review&rft.au=Graham,%20Lindley&rft.aucorp=Univ.%20of%20Texas,%20Austin,%20TX%20(United%20States)&rft.date=2017-03-01&rft.volume=145&rft.issue=3&rft.spage=929&rft.epage=954&rft.pages=929-954&rft.issn=0027-0644&rft.eissn=1520-0493&rft_id=info:doi/10.1175/MWR-D-16-0149.1&rft_dat=%3Cproquest_osti_%3E1924619602%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1924619602&rft_id=info:pmid/&rfr_iscdi=true