Microbiome-wide association studies link dynamic microbial consortia to disease
Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association st...
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| Veröffentlicht in: | Nature (London) 2016-07, Vol.535 (7610), p.94-103 |
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| creator | Gilbert, Jack A. Quinn, Robert A. Debelius, Justine Xu, Zhenjiang Z. Morton, James Garg, Neha Jansson, Janet K. Dorrestein, Pieter C. Knight, Rob |
| description | Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association studies, which are analogous to genome-wide association studies. Early findings point to actionable outcomes of microbiome-wide association studies, although their clinical application has yet to be approved. An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies that are based on the microbiome. |
| doi_str_mv | 10.1038/nature18850 |
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| subjects | 631/326 692/700 Animals Bacteria - classification Bacteria - drug effects Bacteria - metabolism Bacteria - pathogenicity Biomarkers Disease Disease Susceptibility - therapy Genetic aspects Genome-wide association studies Genomes Health Host-parasite relationships Humanities and Social Sciences Humans Metabolism Metabolites Metabolome Microbial Consortia Microbiome Microorganisms multidisciplinary MWAS Prognosis review-article Science |
| title | Microbiome-wide association studies link dynamic microbial consortia to disease |
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