Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase

Plasmodium falciparum, the primary cause of malaria, contains a non-photosynthetic plastid called the apicoplast. The apicoplast exists in most members of the phylum Apicomplexa and has its own genome along with organelle-specific enzymes for its replication. The only DNA polymerase found in the api...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of molecular biology 2016-10, Vol.428 (20), p.3920-3934
Hauptverfasser:	Milton, Morgan E., Choe, Jun-Yong, Honzatko, Richard B., Nelson, Scott W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apicoplasts - enzymology bifunctional enzymes Crystallography, X-Ray DNA exonuclease DNA-Directed DNA Polymerase - chemistry DNA–protein interactions Enzyme catalysis malaria Models, Molecular Plasmodium falciparum - enzymology Protein Conformation Protein Domains
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!