Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein interactions and interdomain dynamics. Several q...

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Veröffentlicht in:	ACS chemical biology 2016-08, Vol.11 (8), p.2293-2303
Hauptverfasser:	Chen, Wei-Hung, Li, Kunhua, Guntaka, Naga Sandhya, Bruner, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Catalytic Domain Chemical structure Crystal structure Crystallography, X-Ray Diketopiperazines - chemistry INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Interfaces Isomerism Monomers Mutagenesis, Site-Directed Peptide Synthases - chemistry Peptide Synthases - genetics Peptide Synthases - metabolism Peptides and proteins Protein Conformation
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