Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

Summary Legalon SIL (SIL) is a chemically hydrophilized version of silibinin, an extract of milk thistle (Silybum marianum) seeds that has exhibited hepatoprotective and antiviral effectiveness against hepatitis C virus (HCV) in patients leading to viral clearance in combination with ribavirin. To e...

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Veröffentlicht in:	Journal of viral hepatitis 2016-09, Vol.23 (9), p.708-717
Hauptverfasser:	DebRoy, S., Hiraga, N., Imamura, M., Hayes, C. N., Akamatsu, S., Canini, L., Perelson, A. S., Pohl, R. T., Persiani, S., Uprichard, S. L., Tateno, C., Dahari, H., Chayama, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals anti-inflammatory Antiviral Agents - administration & dosage Antiviral Agents - pharmacology BASIC BIOLOGICAL SCIENCES Biological Science Cell Line chimeric mice with humanized livers Disease Models, Animal Gene expression Gene Expression Profiling Hepacivirus - isolation & purification Hepatitis Hepatitis C - drug therapy Hepatitis C - virology Humans Interferon Life Sciences Liver - pathology Liver - virology Mice, SCID Microarray Analysis Models, Theoretical RNA, Viral - analysis Sequence Analysis, DNA Serum Albumin - analysis Silymarin - administration & dosage Silymarin - pharmacology Treatment Outcome uPA-SCID viral kinetic modelling Viral Load
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