A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development

Breast cancer is a major cause of mortality in women. The transcription factor SNAI2 has been implicated in the pathogenesis of several types of cancer, including breast cancer of basal origin. Here we show that SNAI2 is also important in the development of breast cancer of luminal origin in MMTV-Er...

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Veröffentlicht in:	Oncogene 2015-09, Vol.34 (36), p.4777-4790
Hauptverfasser:	Castillo-Lluva, S, Hontecillas-Prieto, L, Blanco-Gómez, A, del Mar Sáez-Freire, M, García-Cenador, B, García-Criado, J, Pérez-Andrés, M, Orfao, A, Cañamero, M, Mao, J H, Gridley, T, Castellanos-Martín, A, Pérez-Losada, J
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES 631/67/1347 64 64/110 82/51 96/106 96/31 Animals Apoptosis Apoptosis - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinogenesis Carrier Proteins - genetics Cell Biology Cell Line, Tumor Cell Proliferation - genetics Development and progression ErbB-2 protein Female Gene expression Gene Expression Regulation, Neoplastic Health aspects Human Genetics Humans Internal Medicine Intracellular Signaling Peptides and Proteins Lactation Lactation - genetics Latency Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - secondary Mammary gland Mammary glands Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Medicine Medicine & Public Health Metastases Mice Mice, Knockout Mutants Oncology original-article Pathogenesis Pregnancy Proto-Oncogene Proteins c-akt - biosynthesis Rodents Snail Family Transcription Factors Snail protein STAT3 Transcription Factor - biosynthesis Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics Tumorigenesis Tumors
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