Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism

In bacteria, multiple σ factors compete to associate with the RNA polymerase (RNAP) core enzyme to form a holoenzyme that is required for promoter recognition. During transcription initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions between the σ fact...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (15), p.4051-4056
Hauptverfasser:	Liu, Bin, Zuo, Yuhong, Steitz, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Biological Sciences DNA-Directed RNA Polymerases - metabolism Escherichia coli - metabolism Models, Molecular promoter recognition pyrophosphate release RNA polymerase Sigma Factor - chemistry Sigma Factor - metabolism transcription initiation Transcription, Genetic σS factor
Online-Zugang:	Volltext
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