Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity
The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the sl...
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| Veröffentlicht in: | Optics letters 2016-02, Vol.41 (4), p.753-756 |
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| container_title | Optics letters |
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| creator | Qin, Kun Hu, Shuren Retterer, Scott T Kravchenko, Ivan I Weiss, Sharon M |
| description | The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeter-length sensing regions. An experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated. |
| doi_str_mv | 10.1364/OL.41.000753 |
| format | Article |
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An experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.</description><identifier>ISSN: 0146-9592</identifier><identifier>EISSN: 1539-4794</identifier><identifier>DOI: 10.1364/OL.41.000753</identifier><identifier>PMID: 26872180</identifier><language>eng</language><publisher>United States: Optical Society of America (OSA)</publisher><subject>BASIC BIOLOGICAL SCIENCES ; biological sensing and sensors ; Biosensing Techniques - instrumentation ; Biosensors ; Computer simulation ; interference ; Interferometry - instrumentation ; Light ; Limit of Detection ; Mach-Zehnder interferometers ; nanostructures ; Nucleic acids ; OTHER INSTRUMENTATION ; photonic bandgap materials ; Photonic crystals ; Refractive index ; Refractivity ; Sensitivity ; Silicon Dioxide ; subwavelength structures</subject><ispartof>Optics letters, 2016-02, Vol.41 (4), p.753-756</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-a13956cc7ce070e4d2e01163fc288c09c9b70093b996ae5906ebf9bcdf0d21233</citedby><cites>FETCH-LOGICAL-c389t-a13956cc7ce070e4d2e01163fc288c09c9b70093b996ae5906ebf9bcdf0d21233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3244,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26872180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1237162$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Kun</creatorcontrib><creatorcontrib>Hu, Shuren</creatorcontrib><creatorcontrib>Retterer, Scott T</creatorcontrib><creatorcontrib>Kravchenko, Ivan I</creatorcontrib><creatorcontrib>Weiss, Sharon M</creatorcontrib><creatorcontrib>Oak Ridge National Lab. 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(ORNL), Oak Ridge, TN (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity</atitle><jtitle>Optics letters</jtitle><addtitle>Opt Lett</addtitle><date>2016-02-15</date><risdate>2016</risdate><volume>41</volume><issue>4</issue><spage>753</spage><epage>756</epage><pages>753-756</pages><issn>0146-9592</issn><eissn>1539-4794</eissn><abstract>The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. 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| identifier | ISSN: 0146-9592 |
| ispartof | Optics letters, 2016-02, Vol.41 (4), p.753-756 |
| issn | 0146-9592 1539-4794 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1237162 |
| source | MEDLINE; Optica Publishing Group Journals |
| subjects | BASIC BIOLOGICAL SCIENCES biological sensing and sensors Biosensing Techniques - instrumentation Biosensors Computer simulation interference Interferometry - instrumentation Light Limit of Detection Mach-Zehnder interferometers nanostructures Nucleic acids OTHER INSTRUMENTATION photonic bandgap materials Photonic crystals Refractive index Refractivity Sensitivity Silicon Dioxide subwavelength structures |
| title | Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity |
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