Substrate Promotes Productive Gas Binding in the α‑Ketoglutarate-Dependent Oxygenase FIH

The Fe2+/α-ketoglutarate (αKG)-dependent oxygenases use molecular oxygen to conduct a wide variety of reactions with important biological implications, such as DNA base excision repair, histone demethylation, and the cellular hypoxia response. These enzymes follow a sequential mechanism in which O2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2016-01, Vol.55 (2), p.277-286
Hauptverfasser:	Taabazuing, Cornelius Y, Fermann, Justin, Garman, Scott, Knapp, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption BASIC BIOLOGICAL SCIENCES Chemical structure decarboxylation DNA DNA repair electron paramagnetic resonance spectroscopy Electron Spin Resonance Spectroscopy geometry histones Humans hydroxylation hypoxia hypoxia-inducible factor 1 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY iron Iron - metabolism Ketoglutaric Acids - metabolism Mixed Function Oxygenases - metabolism nitric oxide Nitric Oxide - metabolism Organic reactions oxygen Oxygen - metabolism oxygenases Oxygenases - metabolism Peptides and proteins Protein Structure, Secondary Repressor Proteins - metabolism Substrate Specificity Surface interactions transcriptional activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!