Cysteinate Protonation and Water Hydrogen Bonding at the Active-Site of a Nickel Superoxide Dismutase Metallopeptide-Based Mimic: Implications for the Mechanism of Superoxide Reduction

Nickel-containing superoxide dismutase (NiSOD) is a mononuclear cysteinate-ligated nickel metalloenzyme that catalyzes the disproportionation of superoxide into dioxygen and hydrogen peroxide by cycling between NiII and NiIII oxidation states. All of the ligating residues to nickel are found within...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-11, Vol.136 (45), p.16009-16022
Hauptverfasser:	Shearer, Jason, Peck, Kristy L, Schmitt, Jennifer C, Neupane, Kosh P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic Materials - chemistry Catalytic Domain Cysteine - chemistry Hydrogen Bonding Hydrogen-Ion Concentration Methylation Models, Molecular Molecular Conformation Nickel - metabolism Oxidation-Reduction Protons Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Superoxides - chemistry Water - chemistry
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