Architecture of the fungal nuclear pore inner ring complex

The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ∼425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, reveali...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-10, Vol.350 (6256), p.56-64
Hauptverfasser:	Stuwe, Tobias, Bley, Christopher J., Thierbach, Karsten, Petrovic, Stefan, Schilbach, Sandra, Mayo, Daniel J., Perriches, Thibaud, Rundlet, Emily J., Jeon, Young E., Collins, Leslie N., Huber, Ferdinand M., Lin, Daniel H., Paduch, Marcin, Koide, Akiko, Lu, Vincent, Fischer, Jessica, Hurt, Ed, Koide, Shohei, Kossiakoff, Anthony A., Hoelz, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Architecture Chaetomium - metabolism Chaetomium - ultrastructure Channels Cytoplasm Diffusion barriers Fungal Proteins - chemistry Fungal Proteins - ultrastructure Fungi Metazoa Molecular Sequence Data Nuclear Pore - metabolism Nuclear Pore - ultrastructure Nuclear Pore Complex Proteins - chemistry Nuclear Pore Complex Proteins - ultrastructure Nuclear power generation Nuclear Proteins - chemistry Nuclear Proteins - ultrastructure Nuclei Porosity Protein Binding Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary Proteins RESEARCH ARTICLE Transport
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