Influence of Natural Organic Matter and Surface Charge on the Toxicity and Bioaccumulation of Functionalized Ceria Nanoparticles in Caenorhabditis elegans
The objective of this study was to investigate the role of the CeO2 nanoparticle (NP) surface charge and the presence of natural organic matter (NOM) in determining bioavailability and toxicity to the model soil organism Caenorhabditis elegans. We synthesized CeO2-NPs functionalized with positively...
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| Veröffentlicht in: | Environmental science & technology 2014-01, Vol.48 (2), p.1280-1289 |
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| creator | Collin, Blanche Oostveen, Emily Tsyusko, Olga V Unrine, Jason M |
| description | The objective of this study was to investigate the role of the CeO2 nanoparticle (NP) surface charge and the presence of natural organic matter (NOM) in determining bioavailability and toxicity to the model soil organism Caenorhabditis elegans. We synthesized CeO2-NPs functionalized with positively charged, negatively charged, and neutral coatings. The positively charged CeO2-NPs were significantly more toxic to C. elegans and bioaccumulated to a greater extent than the neutral and negatively charged CeO2-NPs. Surface charge also affected the oxidation state of Ce in C. elegans tissues after uptake. Greater reduction of Ce from Ce (IV) to Ce (III) was found in C. elegans, when exposed to the neutral and negatively charged relative to positively charged CeO2-NPs. The addition of humic acid (HA) to the exposure media significantly decreased the toxicity of CeO2-NPs, and the ratio of CeO2-NPs to HA influenced Ce bioaccumulation. When the concentration of HA was higher than the CeO2-NP concentration, Ce bioaccumulation decreased. These results suggest that the nature of the pristine coatings as a determinant of hazard may be greatly reduced once CeO2-NPs enter the environment and are coated with NOM. |
| doi_str_mv | 10.1021/es404503c |
| format | Article |
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We synthesized CeO2-NPs functionalized with positively charged, negatively charged, and neutral coatings. The positively charged CeO2-NPs were significantly more toxic to C. elegans and bioaccumulated to a greater extent than the neutral and negatively charged CeO2-NPs. Surface charge also affected the oxidation state of Ce in C. elegans tissues after uptake. Greater reduction of Ce from Ce (IV) to Ce (III) was found in C. elegans, when exposed to the neutral and negatively charged relative to positively charged CeO2-NPs. The addition of humic acid (HA) to the exposure media significantly decreased the toxicity of CeO2-NPs, and the ratio of CeO2-NPs to HA influenced Ce bioaccumulation. When the concentration of HA was higher than the CeO2-NP concentration, Ce bioaccumulation decreased. These results suggest that the nature of the pristine coatings as a determinant of hazard may be greatly reduced once CeO2-NPs enter the environment and are coated with NOM.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es404503c</identifier><identifier>PMID: 24372151</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Bioaccumulation ; Biological Availability ; Caenorhabditis elegans ; Caenorhabditis elegans - drug effects ; Caenorhabditis elegans - metabolism ; Cerium - toxicity ; Cross-disciplinary physics: materials science; rheology ; Environmental Sciences ; Exact sciences and technology ; Humic Substances - analysis ; Ligands ; Materials science ; Metal Nanoparticles - toxicity ; Metals ; Nanoparticles ; Nanoscale materials and structures: fabrication and characterization ; Nematodes ; Organic chemicals ; Physics ; Spectrometry, X-Ray Emission ; Static Electricity ; Toxicity ; Toxicity Tests ; Worms</subject><ispartof>Environmental science & technology, 2014-01, Vol.48 (2), p.1280-1289</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Jan 21, 2014</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a533t-140fac7a89759f629381680c77cc07a205cd5b3af5053eab84b427806b75a9093</citedby><cites>FETCH-LOGICAL-a533t-140fac7a89759f629381680c77cc07a205cd5b3af5053eab84b427806b75a9093</cites><orcidid>0000-0001-6173-1227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es404503c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es404503c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28260095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24372151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01654597$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1162678$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Collin, Blanche</creatorcontrib><creatorcontrib>Oostveen, Emily</creatorcontrib><creatorcontrib>Tsyusko, Olga V</creatorcontrib><creatorcontrib>Unrine, Jason M</creatorcontrib><creatorcontrib>Brookhaven National Laboratory (BNL)</creatorcontrib><title>Influence of Natural Organic Matter and Surface Charge on the Toxicity and Bioaccumulation of Functionalized Ceria Nanoparticles in Caenorhabditis elegans</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>The objective of this study was to investigate the role of the CeO2 nanoparticle (NP) surface charge and the presence of natural organic matter (NOM) in determining bioavailability and toxicity to the model soil organism Caenorhabditis elegans. We synthesized CeO2-NPs functionalized with positively charged, negatively charged, and neutral coatings. The positively charged CeO2-NPs were significantly more toxic to C. elegans and bioaccumulated to a greater extent than the neutral and negatively charged CeO2-NPs. Surface charge also affected the oxidation state of Ce in C. elegans tissues after uptake. Greater reduction of Ce from Ce (IV) to Ce (III) was found in C. elegans, when exposed to the neutral and negatively charged relative to positively charged CeO2-NPs. The addition of humic acid (HA) to the exposure media significantly decreased the toxicity of CeO2-NPs, and the ratio of CeO2-NPs to HA influenced Ce bioaccumulation. When the concentration of HA was higher than the CeO2-NP concentration, Ce bioaccumulation decreased. These results suggest that the nature of the pristine coatings as a determinant of hazard may be greatly reduced once CeO2-NPs enter the environment and are coated with NOM.</description><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Biological Availability</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - drug effects</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Cerium - toxicity</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Environmental Sciences</subject><subject>Exact sciences and technology</subject><subject>Humic Substances - analysis</subject><subject>Ligands</subject><subject>Materials science</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Metals</subject><subject>Nanoparticles</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nematodes</subject><subject>Organic chemicals</subject><subject>Physics</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Static Electricity</subject><subject>Toxicity</subject><subject>Toxicity Tests</subject><subject>Worms</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0kFv0zAUB_AIgVg3OPAFkAWaBIfCsx3HyXFUjE0q7MCQuEUvjrN4cu3OdhDjo_BpcWlpEZxsWT-9_7P9iuIZhTcUGH2rYwmlAK4eFDMqGMxFLejDYgZA-bzh1dej4jjGWwBgHOrHxREruWRU0Fnx89INdtJOaeIH8gnTFNCSq3CDzijyEVPSgaDryecpDJjVYsRwk7EjadTk2n83yqT73-Sd8ajUtJosJpNBLng-ObXZozU_dE8WOhjMKc6vMSSjrI7EOLJA7XwYsetNMpFoq3N8fFI8GtBG_XS3nhRfzt9fLy7my6sPl4uz5RwF52lOS8iNSawbKZqhYg2vaVWDklIpkMhAqF50HAcBgmvs6rIrmayh6qTABhp-UrzY1vUxmTbm62g1Ku-cVqmltGKVrDN6vUUj2nYdzArDfevRtBdny3ZzBrQSpWjkN5rtq61dB3836ZjalYlKW4tO-ym2VABIIYGKTF_-Q2_9FPJzZVU2jElOKRzCVfAxBj3sO6DQbiag3U9Ats93Fadupfu9_PPlGZzuAEaFdgjolIkHV7MKoBEHhyr-1dV_gb8AG9HDGA</recordid><startdate>20140121</startdate><enddate>20140121</enddate><creator>Collin, Blanche</creator><creator>Oostveen, Emily</creator><creator>Tsyusko, Olga V</creator><creator>Unrine, Jason M</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7TV</scope><scope>1XC</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-6173-1227</orcidid></search><sort><creationdate>20140121</creationdate><title>Influence of Natural Organic Matter and Surface Charge on the Toxicity and Bioaccumulation of Functionalized Ceria Nanoparticles in Caenorhabditis elegans</title><author>Collin, Blanche ; Oostveen, Emily ; Tsyusko, Olga V ; Unrine, Jason M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a533t-140fac7a89759f629381680c77cc07a205cd5b3af5053eab84b427806b75a9093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Bioaccumulation</topic><topic>Biological Availability</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - drug effects</topic><topic>Caenorhabditis elegans - metabolism</topic><topic>Cerium - toxicity</topic><topic>Cross-disciplinary physics: materials science; rheology</topic><topic>Environmental Sciences</topic><topic>Exact sciences and technology</topic><topic>Humic Substances - analysis</topic><topic>Ligands</topic><topic>Materials science</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Metals</topic><topic>Nanoparticles</topic><topic>Nanoscale materials and structures: fabrication and characterization</topic><topic>Nematodes</topic><topic>Organic chemicals</topic><topic>Physics</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Static Electricity</topic><topic>Toxicity</topic><topic>Toxicity Tests</topic><topic>Worms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collin, Blanche</creatorcontrib><creatorcontrib>Oostveen, Emily</creatorcontrib><creatorcontrib>Tsyusko, Olga V</creatorcontrib><creatorcontrib>Unrine, Jason M</creatorcontrib><creatorcontrib>Brookhaven National Laboratory (BNL)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>OSTI.GOV</collection><jtitle>Environmental science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collin, Blanche</au><au>Oostveen, Emily</au><au>Tsyusko, Olga V</au><au>Unrine, Jason M</au><aucorp>Brookhaven National Laboratory (BNL)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Natural Organic Matter and Surface Charge on the Toxicity and Bioaccumulation of Functionalized Ceria Nanoparticles in Caenorhabditis elegans</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2014-01-21</date><risdate>2014</risdate><volume>48</volume><issue>2</issue><spage>1280</spage><epage>1289</epage><pages>1280-1289</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>The objective of this study was to investigate the role of the CeO2 nanoparticle (NP) surface charge and the presence of natural organic matter (NOM) in determining bioavailability and toxicity to the model soil organism Caenorhabditis elegans. We synthesized CeO2-NPs functionalized with positively charged, negatively charged, and neutral coatings. The positively charged CeO2-NPs were significantly more toxic to C. elegans and bioaccumulated to a greater extent than the neutral and negatively charged CeO2-NPs. Surface charge also affected the oxidation state of Ce in C. elegans tissues after uptake. Greater reduction of Ce from Ce (IV) to Ce (III) was found in C. elegans, when exposed to the neutral and negatively charged relative to positively charged CeO2-NPs. The addition of humic acid (HA) to the exposure media significantly decreased the toxicity of CeO2-NPs, and the ratio of CeO2-NPs to HA influenced Ce bioaccumulation. When the concentration of HA was higher than the CeO2-NP concentration, Ce bioaccumulation decreased. These results suggest that the nature of the pristine coatings as a determinant of hazard may be greatly reduced once CeO2-NPs enter the environment and are coated with NOM.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>24372151</pmid><doi>10.1021/es404503c</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6173-1227</orcidid></addata></record> |
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| identifier | ISSN: 0013-936X |
| ispartof | Environmental science & technology, 2014-01, Vol.48 (2), p.1280-1289 |
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| subjects | Animals Bioaccumulation Biological Availability Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - metabolism Cerium - toxicity Cross-disciplinary physics: materials science rheology Environmental Sciences Exact sciences and technology Humic Substances - analysis Ligands Materials science Metal Nanoparticles - toxicity Metals Nanoparticles Nanoscale materials and structures: fabrication and characterization Nematodes Organic chemicals Physics Spectrometry, X-Ray Emission Static Electricity Toxicity Toxicity Tests Worms |
| title | Influence of Natural Organic Matter and Surface Charge on the Toxicity and Bioaccumulation of Functionalized Ceria Nanoparticles in Caenorhabditis elegans |
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