Probing Conformational Changes in Ape1 during the Progression of Base Excision Repair

Abasic (AP) sites are the most common lesions arising in genomic DNA. Repair of this potentially mutagenic DNA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifically recognizes and cleaves the DNA backbone 5′ to the AP site. Ape1 is one of the major proteins in...

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Veröffentlicht in:	Biochemistry (Easton) 2010-05, Vol.49 (18), p.3786-3796
Hauptverfasser:	Yu, Eizadora, Gaucher, Sara P, Hadi, Masood Z
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - genetics DNA - metabolism DNA Damage DNA Polymerase beta - genetics DNA Polymerase beta - metabolism DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Humans Molecular Conformation Protein Binding Protein Conformation Protein Structure, Tertiary
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