Broad Substrate Specificity of the Loading Didomain of the Lipomycin Polyketide Synthase

LipPks1, a polyketide synthase subunit of the lipomycin synthase, is believed to catalyze the polyketide chain initiation reaction using isobutyryl-CoA as a substrate, followed by an elongation reaction with methylmalonyl-CoA to start the biosynthesis of antibiotic α-lipomycin in Streptomyces aureof...

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Veröffentlicht in:	Biochemistry (Easton) 2013-06, Vol.52 (22), p.3791-3793
Hauptverfasser:	Yuzawa, Satoshi, Eng, Clara H, Katz, Leonard, Keasling, Jay D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Escherichia coli - enzymology Glycosides - biosynthesis Polyenes Polyketide Synthases - chemistry Polyketide Synthases - metabolism Protein Structure, Tertiary Streptomyces aureofaciens - enzymology Substrate Specificity
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