Synthetic biology and the development of tools for metabolic engineering

Synthetic biology and the development of tools for metabolic engineering

Synthetic biology can significantly advance metabolic engineering by contributing tools (minimal hosts, vectors, genetic controllers, characterized enzymes). The development of these tools significantly reduced the costs and time to develop the antimalarial drug artemisinin, but the availability of...

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Veröffentlicht in:Metabolic engineering 2012-05, Vol.14 (3), p.189-195
1. Verfasser: Keasling, Jay D.
Format: Artikel
Sprache:eng
Schlagworte:
Antimalarials - chemical synthesis
Antimalarials - economics
Antimalarials - metabolism
Artemisinin
Artemisinins - chemical synthesis
Artemisinins - economics
Artemisinins - metabolism
Drug Design
Engineering
Enzymes
Genetic
Hosts
Lactones - chemical synthesis
Lactones - economics
Lactones - metabolism
Metabolic
Metabolic Engineering - economics
Metabolic Engineering - methods
Metabolic Engineering - trends
Synthetic Biology - economics
Synthetic Biology - methods
Synthetic Biology - trends
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Zusammenfassung:Synthetic biology can significantly advance metabolic engineering by contributing tools (minimal hosts, vectors, genetic controllers, characterized enzymes). The development of these tools significantly reduced the costs and time to develop the antimalarial drug artemisinin, but the availability of more tools could have reduced these costs substantially.
ISSN:1096-7176
1096-7184
DOI:10.1016/j.ymben.2012.01.004