Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy
Multifunctional hybrid nanoparticles (NPs, ∼100 nm) that combine magnetic Fe 3 O 4 nanocrystals and fluorescent carbon dots (CDs) in porous carbon (C) were successfully synthesized using a one-pot solvothermal method by simply increasing the H 2 O 2 concentration. The resultant Fe 3 O 4 @C-CDs hybri...
Gespeichert in:
| Veröffentlicht in: | Biomaterials science 2014-01, Vol.2 (6), p.915-923 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 923 |
|---|---|
| container_issue | 6 |
| container_start_page | 915 |
| container_title | Biomaterials science |
| container_volume | 2 |
| creator | Wang, Hui Shen, Jing Li, Yingyu Wei, Zengyan Cao, Guixin Gai, Zheng Hong, Kunlun Banerjee, Probal Zhou, Shuiqin |
| description | Multifunctional hybrid nanoparticles (NPs, ∼100 nm) that combine magnetic Fe
3
O
4
nanocrystals and fluorescent carbon dots (CDs) in porous carbon (C) were successfully synthesized using a one-pot solvothermal method by simply increasing the H
2
O
2
concentration. The resultant Fe
3
O
4
@C-CDs hybrid NPs not only demonstrate excellent magnetic responsive properties (
M
s
= 32.5 emu g
−1
) and magnetic resonance imaging ability (
r
*2 = 674.4 mM
−1
s
−1
) from the Fe
3
O
4
nanocrystal core, but also exhibit intriguing photoluminescent (quantum yield ∼6.8%) properties including upconversion fluorescence and excellent photostability from the CDs produced in the porous carbon. The hybrid NPs can enter the intracellular region and illuminate mouse melanoma B16F10 cells under different excitation wavelengths. Meanwhile, the mesoporous carbon shell and hydrophilic surface functional groups endow the hybrid NPs with high loading capacity (835 mg g
−1
) for the anti-cancer drug doxorubicin and excellent stability in aqueous solutions. More importantly, the hybrid NPs can absorb and convert near-infrared (NIR) light to heat due to the existence of CDs, and thus, can realise NIR-controlled drug release and combined photothermo/chemotherapy for high therapeutic efficacy. Such nanostructured Fe
3
O
4
@C-CDs hybrid NPs demonstrate great promise towards advanced nanoplatforms for simultaneous imaging diagnostics and high efficacy therapy. |
| doi_str_mv | 10.1039/c3bm60297d |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_1131506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1671526088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-7dba817ed5157a07c7a16b7de79257c6dcea6ec3c288385f8e980d0c39ab63e93</originalsourceid><addsrcrecordid>eNqFkU2O1DAQhSMEEqNhNpzAYoUQATtObGcJza80Izawjip2JW2U2KHsIGbHHTgCN-MkuGnEltq8kup7r6Sqqnoo-DPBZf_cynFVvOm1u1NdNLzVdWva_u6_XvL71VVKn3kprXuuxEX18wbmgNlb5ikGFr95h7--_5iWPRImiyEzCzSWkYs5MR8yzgQZHQsQ4gZUrAsmNkViboelXqODhfkVZh_mpywgUO3DREDFs_j5mOsSvMWQ_Fdkjvb5tIA8EoPg2HaMOeYj0lpSTgrb7YPq3gRLwqu_ell9evP64-Fdff3h7fvDi-vatlLkWrsRjNDoOtFp4NpqEGrUDnXfdNoqZxEUWmkbY6TpJoO94Y5b2cOoJPbysnp0zo0p-yFZn9EebQwBbR6EkKLjqkCPz9BG8cuOKQ-rL3daFggY9zQ0LTem7Xpl_osKpUXXqMIX9MkZtRRTIpyGjcoN6XYQfDg9dzjIlzd_nvtK_gZvKZwI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1671526088</pqid></control><display><type>article</type><title>Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Wang, Hui ; Shen, Jing ; Li, Yingyu ; Wei, Zengyan ; Cao, Guixin ; Gai, Zheng ; Hong, Kunlun ; Banerjee, Probal ; Zhou, Shuiqin</creator><creatorcontrib>Wang, Hui ; Shen, Jing ; Li, Yingyu ; Wei, Zengyan ; Cao, Guixin ; Gai, Zheng ; Hong, Kunlun ; Banerjee, Probal ; Zhou, Shuiqin ; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States) ; Center for Nanophase Materials Sciences (CNMS)</creatorcontrib><description>Multifunctional hybrid nanoparticles (NPs, ∼100 nm) that combine magnetic Fe
3
O
4
nanocrystals and fluorescent carbon dots (CDs) in porous carbon (C) were successfully synthesized using a one-pot solvothermal method by simply increasing the H
2
O
2
concentration. The resultant Fe
3
O
4
@C-CDs hybrid NPs not only demonstrate excellent magnetic responsive properties (
M
s
= 32.5 emu g
−1
) and magnetic resonance imaging ability (
r
*2 = 674.4 mM
−1
s
−1
) from the Fe
3
O
4
nanocrystal core, but also exhibit intriguing photoluminescent (quantum yield ∼6.8%) properties including upconversion fluorescence and excellent photostability from the CDs produced in the porous carbon. The hybrid NPs can enter the intracellular region and illuminate mouse melanoma B16F10 cells under different excitation wavelengths. Meanwhile, the mesoporous carbon shell and hydrophilic surface functional groups endow the hybrid NPs with high loading capacity (835 mg g
−1
) for the anti-cancer drug doxorubicin and excellent stability in aqueous solutions. More importantly, the hybrid NPs can absorb and convert near-infrared (NIR) light to heat due to the existence of CDs, and thus, can realise NIR-controlled drug release and combined photothermo/chemotherapy for high therapeutic efficacy. Such nanostructured Fe
3
O
4
@C-CDs hybrid NPs demonstrate great promise towards advanced nanoplatforms for simultaneous imaging diagnostics and high efficacy therapy.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/c3bm60297d</identifier><language>eng</language><publisher>United States</publisher><subject>Cadmium sulfides ; Carbon ; Drugs ; Effectiveness ; Imaging ; Nanocrystals ; Nanostructure ; Therapy</subject><ispartof>Biomaterials science, 2014-01, Vol.2 (6), p.915-923</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-7dba817ed5157a07c7a16b7de79257c6dcea6ec3c288385f8e980d0c39ab63e93</citedby><cites>FETCH-LOGICAL-c431t-7dba817ed5157a07c7a16b7de79257c6dcea6ec3c288385f8e980d0c39ab63e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/1131506$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Shen, Jing</creatorcontrib><creatorcontrib>Li, Yingyu</creatorcontrib><creatorcontrib>Wei, Zengyan</creatorcontrib><creatorcontrib>Cao, Guixin</creatorcontrib><creatorcontrib>Gai, Zheng</creatorcontrib><creatorcontrib>Hong, Kunlun</creatorcontrib><creatorcontrib>Banerjee, Probal</creatorcontrib><creatorcontrib>Zhou, Shuiqin</creatorcontrib><creatorcontrib>Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)</creatorcontrib><creatorcontrib>Center for Nanophase Materials Sciences (CNMS)</creatorcontrib><title>Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy</title><title>Biomaterials science</title><description>Multifunctional hybrid nanoparticles (NPs, ∼100 nm) that combine magnetic Fe
3
O
4
nanocrystals and fluorescent carbon dots (CDs) in porous carbon (C) were successfully synthesized using a one-pot solvothermal method by simply increasing the H
2
O
2
concentration. The resultant Fe
3
O
4
@C-CDs hybrid NPs not only demonstrate excellent magnetic responsive properties (
M
s
= 32.5 emu g
−1
) and magnetic resonance imaging ability (
r
*2 = 674.4 mM
−1
s
−1
) from the Fe
3
O
4
nanocrystal core, but also exhibit intriguing photoluminescent (quantum yield ∼6.8%) properties including upconversion fluorescence and excellent photostability from the CDs produced in the porous carbon. The hybrid NPs can enter the intracellular region and illuminate mouse melanoma B16F10 cells under different excitation wavelengths. Meanwhile, the mesoporous carbon shell and hydrophilic surface functional groups endow the hybrid NPs with high loading capacity (835 mg g
−1
) for the anti-cancer drug doxorubicin and excellent stability in aqueous solutions. More importantly, the hybrid NPs can absorb and convert near-infrared (NIR) light to heat due to the existence of CDs, and thus, can realise NIR-controlled drug release and combined photothermo/chemotherapy for high therapeutic efficacy. Such nanostructured Fe
3
O
4
@C-CDs hybrid NPs demonstrate great promise towards advanced nanoplatforms for simultaneous imaging diagnostics and high efficacy therapy.</description><subject>Cadmium sulfides</subject><subject>Carbon</subject><subject>Drugs</subject><subject>Effectiveness</subject><subject>Imaging</subject><subject>Nanocrystals</subject><subject>Nanostructure</subject><subject>Therapy</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkU2O1DAQhSMEEqNhNpzAYoUQATtObGcJza80Izawjip2JW2U2KHsIGbHHTgCN-MkuGnEltq8kup7r6Sqqnoo-DPBZf_cynFVvOm1u1NdNLzVdWva_u6_XvL71VVKn3kprXuuxEX18wbmgNlb5ikGFr95h7--_5iWPRImiyEzCzSWkYs5MR8yzgQZHQsQ4gZUrAsmNkViboelXqODhfkVZh_mpywgUO3DREDFs_j5mOsSvMWQ_Fdkjvb5tIA8EoPg2HaMOeYj0lpSTgrb7YPq3gRLwqu_ell9evP64-Fdff3h7fvDi-vatlLkWrsRjNDoOtFp4NpqEGrUDnXfdNoqZxEUWmkbY6TpJoO94Y5b2cOoJPbysnp0zo0p-yFZn9EebQwBbR6EkKLjqkCPz9BG8cuOKQ-rL3daFggY9zQ0LTem7Xpl_osKpUXXqMIX9MkZtRRTIpyGjcoN6XYQfDg9dzjIlzd_nvtK_gZvKZwI</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Wang, Hui</creator><creator>Shen, Jing</creator><creator>Li, Yingyu</creator><creator>Wei, Zengyan</creator><creator>Cao, Guixin</creator><creator>Gai, Zheng</creator><creator>Hong, Kunlun</creator><creator>Banerjee, Probal</creator><creator>Zhou, Shuiqin</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20140101</creationdate><title>Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy</title><author>Wang, Hui ; Shen, Jing ; Li, Yingyu ; Wei, Zengyan ; Cao, Guixin ; Gai, Zheng ; Hong, Kunlun ; Banerjee, Probal ; Zhou, Shuiqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-7dba817ed5157a07c7a16b7de79257c6dcea6ec3c288385f8e980d0c39ab63e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cadmium sulfides</topic><topic>Carbon</topic><topic>Drugs</topic><topic>Effectiveness</topic><topic>Imaging</topic><topic>Nanocrystals</topic><topic>Nanostructure</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Shen, Jing</creatorcontrib><creatorcontrib>Li, Yingyu</creatorcontrib><creatorcontrib>Wei, Zengyan</creatorcontrib><creatorcontrib>Cao, Guixin</creatorcontrib><creatorcontrib>Gai, Zheng</creatorcontrib><creatorcontrib>Hong, Kunlun</creatorcontrib><creatorcontrib>Banerjee, Probal</creatorcontrib><creatorcontrib>Zhou, Shuiqin</creatorcontrib><creatorcontrib>Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)</creatorcontrib><creatorcontrib>Center for Nanophase Materials Sciences (CNMS)</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hui</au><au>Shen, Jing</au><au>Li, Yingyu</au><au>Wei, Zengyan</au><au>Cao, Guixin</au><au>Gai, Zheng</au><au>Hong, Kunlun</au><au>Banerjee, Probal</au><au>Zhou, Shuiqin</au><aucorp>Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)</aucorp><aucorp>Center for Nanophase Materials Sciences (CNMS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy</atitle><jtitle>Biomaterials science</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2</volume><issue>6</issue><spage>915</spage><epage>923</epage><pages>915-923</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>Multifunctional hybrid nanoparticles (NPs, ∼100 nm) that combine magnetic Fe
3
O
4
nanocrystals and fluorescent carbon dots (CDs) in porous carbon (C) were successfully synthesized using a one-pot solvothermal method by simply increasing the H
2
O
2
concentration. The resultant Fe
3
O
4
@C-CDs hybrid NPs not only demonstrate excellent magnetic responsive properties (
M
s
= 32.5 emu g
−1
) and magnetic resonance imaging ability (
r
*2 = 674.4 mM
−1
s
−1
) from the Fe
3
O
4
nanocrystal core, but also exhibit intriguing photoluminescent (quantum yield ∼6.8%) properties including upconversion fluorescence and excellent photostability from the CDs produced in the porous carbon. The hybrid NPs can enter the intracellular region and illuminate mouse melanoma B16F10 cells under different excitation wavelengths. Meanwhile, the mesoporous carbon shell and hydrophilic surface functional groups endow the hybrid NPs with high loading capacity (835 mg g
−1
) for the anti-cancer drug doxorubicin and excellent stability in aqueous solutions. More importantly, the hybrid NPs can absorb and convert near-infrared (NIR) light to heat due to the existence of CDs, and thus, can realise NIR-controlled drug release and combined photothermo/chemotherapy for high therapeutic efficacy. Such nanostructured Fe
3
O
4
@C-CDs hybrid NPs demonstrate great promise towards advanced nanoplatforms for simultaneous imaging diagnostics and high efficacy therapy.</abstract><cop>United States</cop><doi>10.1039/c3bm60297d</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4830 |
| ispartof | Biomaterials science, 2014-01, Vol.2 (6), p.915-923 |
| issn | 2047-4830 2047-4849 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1131506 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cadmium sulfides Carbon Drugs Effectiveness Imaging Nanocrystals Nanostructure Therapy |
| title | Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T17%3A19%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20iron%20oxide%E2%80%93fluorescent%20carbon%20dots%20integrated%20nanoparticles%20for%20dual-modal%20imaging,%20near-infrared%20light-responsive%20drug%20carrier%20and%20photothermal%20therapy&rft.jtitle=Biomaterials%20science&rft.au=Wang,%20Hui&rft.aucorp=Oak%20Ridge%20National%20Lab.%20(ORNL),%20Oak%20Ridge,%20TN%20(United%20States)&rft.date=2014-01-01&rft.volume=2&rft.issue=6&rft.spage=915&rft.epage=923&rft.pages=915-923&rft.issn=2047-4830&rft.eissn=2047-4849&rft_id=info:doi/10.1039/c3bm60297d&rft_dat=%3Cproquest_osti_%3E1671526088%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1671526088&rft_id=info:pmid/&rfr_iscdi=true |