Structural and functional insights into alphavirus polyprotein processing and pathogenesis

Alphaviruses, a group of positive-sense RNA viruses, are globally distributed arboviruses capable of causing rash, arthritis, encephalitis, and death in humans. The viral replication machinery consists of four nonstructural proteins (nsP1–4) produced as a single polyprotein. Processing of the polypr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-10, Vol.109 (41), p.16534-16539
Hauptverfasser:	Shin, Gyehwa, Yost, Samantha A, Miller, Matthew T, Elrod, Elizabeth J, Grakoui, Arash, Marcotrigiano, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Alphavirus - genetics Alphavirus - metabolism Alphavirus - pathogenicity Alphavirus Infections - virology Alphaviruses Amino Acid Sequence Animals arboviruses arthritis Binding sites Binding Sites - genetics Biological Sciences Blotting, Western Cell Line Crystallography, X-Ray death Dengue virus encephalitis Genetic mutation genome Genomics Genotype & phenotype Hepatitis C virus Human immunodeficiency virus humans Infections Mice Mice, Inbred BALB C Models, Molecular Molecular Sequence Data Mutation pathogenesis pathogenicity phenotype Polyproteins Polyproteins - chemistry Polyproteins - genetics Polyproteins - metabolism Protein Structure, Secondary Protein Structure, Tertiary proteinases Proteins Proteolysis Ribonucleic acid RNA Sequence Homology, Amino Acid Sindbis Virus temperature viral nonstructural proteins Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virulence - genetics virus replication Viruses Zinc
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