A monoclinic crystal form of casein kinase 1[delta]

A monoclinic crystal form of casein kinase 1[delta]

Casein kinase 1 [delta] (CK1[delta]) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1[delta] have previously been determined and this article reports...

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Veröffentlicht in:Acta crystallographica. Section F, Structural biology communications Structural biology communications, 2014-08, Vol.69 (10), p.1077
Hauptverfasser: Zeringo, Nicholas A, Murphy, Lea, McCloskey, Eric A, Rohal, Loren, Bellizzi, John J
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Crystal structure
Kinases
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container_title Acta crystallographica. Section F, Structural biology communications
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creator Zeringo, Nicholas A
Murphy, Lea
McCloskey, Eric A
Rohal, Loren
Bellizzi, John J
description Casein kinase 1 [delta] (CK1[delta]) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1[delta] have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P21. Comparison of CK1[delta] crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the [beta]-sheet region of the N-terminal lobe were observed. [PUBLICATION ABSTRACT]
doi_str_mv 10.1107/S1744309113023403
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Kinases
title A monoclinic crystal form of casein kinase 1[delta]
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