Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform
A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This so...
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| Veröffentlicht in: | Journal of mass spectrometry. 2010-03, Vol.45 (3), p.252-260 |
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| container_title | Journal of mass spectrometry. |
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| creator | Kertesz, Vilmos Van Berkel, Gary J. |
| description | A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole‐body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction‐based surface sampling techniques. Published in 2009 by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jms.1709 |
| format | Article |
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Drug treatments ; Reproducibility of Results ; Robotics - instrumentation ; Sampling ; Sensitivity and Specificity ; Software ; Spectrometry, Mass, Electrospray Ionization - instrumentation ; surface sampling ; thin tissue sections</subject><ispartof>Journal of mass spectrometry., 2010-03, Vol.45 (3), p.252-260</ispartof><rights>This article is a US Government work and is in the public domain in the USA. 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(ORNL), Oak Ridge, TN (United States)</creatorcontrib><title>Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform</title><title>Journal of mass spectrometry.</title><addtitle>J. Mass Spectrom</addtitle><description>A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole‐body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction‐based surface sampling techniques. Published in 2009 by John Wiley & Sons, Ltd.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Chromatography, Supercritical Fluid - instrumentation</subject><subject>Computer programs</subject><subject>dried blood spots</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>General pharmacology</subject><subject>Ionization</subject><subject>Liquids</subject><subject>MALDI spots</subject><subject>mass spectrometry</subject><subject>Medical sciences</subject><subject>Microfluidic Analytical Techniques - instrumentation</subject><subject>Nanocomposites</subject><subject>nanoelectrospray</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Nanotechnology - instrumentation</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>Robotics - instrumentation</subject><subject>Sampling</subject><subject>Sensitivity and Specificity</subject><subject>Software</subject><subject>Spectrometry, Mass, Electrospray Ionization - instrumentation</subject><subject>surface sampling</subject><subject>thin tissue sections</subject><issn>1076-5174</issn><issn>1096-9888</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90V9v1SAUAPDGaNycJn4CQ0yMvnQChQKPZnFTM_XB6RJfyCmljklLBzTuGj-8XG_dnvQJcvidP-RU1WOCDwnG9OXlmA6JwOpOtU-wamslpby7vYu25kSwvepBSpcYY6VYe7_aoyUJM8L2q1_Hi_cbBEsOI2TbI--uFtcje50jmOzCVHeQSjwtcQBjUYJx9m76hmDqUXl2P2Gr0JL-BJG5cPOaEkMXsjNogilYb02OIc0RNmj2kIcQx4fVvQF8so_W86D6fPz67OhNffrx5O3Rq9PacMJUTRsqsDFWEEX7vqOiH6i0vMOkxx1piRgM5phSBRxMo4xsCcMtVdx2jHHSNwfV013dkLLTybhszYUJ01Rm0gRL0jakoOc7NMdwtdiU9eiSsd7DZMOStGiahlHKaZEv_itJmUW2kgt2S035e4p20HN0I8RNQXq7Ol1Wp7erK_TJWnXpRtvfwL-7KuDZCiAZ8EOEybh06yiTQnBZXL1zP5y3m3821O_ef1obr96lbK9vPMTvuhWN4Pr8w4nm5Eyp869Cf2l-A3OEv0E</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Kertesz, Vilmos</creator><creator>Van Berkel, Gary J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201003</creationdate><title>Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform</title><author>Kertesz, Vilmos ; Van Berkel, Gary J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5149-23270cce7192ddb27df28e5b01d0b1617fc050229a5ac39c861406295eb4451d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Chromatography, Supercritical Fluid - instrumentation</topic><topic>Computer programs</topic><topic>dried blood spots</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>General pharmacology</topic><topic>Ionization</topic><topic>Liquids</topic><topic>MALDI spots</topic><topic>mass spectrometry</topic><topic>Medical sciences</topic><topic>Microfluidic Analytical Techniques - instrumentation</topic><topic>Nanocomposites</topic><topic>nanoelectrospray</topic><topic>Nanomaterials</topic><topic>Nanostructure</topic><topic>Nanotechnology - instrumentation</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Robotics - instrumentation</topic><topic>Sampling</topic><topic>Sensitivity and Specificity</topic><topic>Software</topic><topic>Spectrometry, Mass, Electrospray Ionization - instrumentation</topic><topic>surface sampling</topic><topic>thin tissue sections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kertesz, Vilmos</creatorcontrib><creatorcontrib>Van Berkel, Gary J.</creatorcontrib><creatorcontrib>Oak Ridge National Lab. 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(ORNL), Oak Ridge, TN (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2010-03</date><risdate>2010</risdate><volume>45</volume><issue>3</issue><spage>252</spage><epage>260</epage><pages>252-260</pages><issn>1076-5174</issn><issn>1096-9888</issn><eissn>1096-9888</eissn><abstract>A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole‐body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction‐based surface sampling techniques. Published in 2009 by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20020414</pmid><doi>10.1002/jms.1709</doi><tpages>9</tpages></addata></record> |
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| subjects | Analysis Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Chromatography, Supercritical Fluid - instrumentation Computer programs dried blood spots Equipment Design Equipment Failure Analysis General pharmacology Ionization Liquids MALDI spots mass spectrometry Medical sciences Microfluidic Analytical Techniques - instrumentation Nanocomposites nanoelectrospray Nanomaterials Nanostructure Nanotechnology - instrumentation Pharmacology. Drug treatments Reproducibility of Results Robotics - instrumentation Sampling Sensitivity and Specificity Software Spectrometry, Mass, Electrospray Ionization - instrumentation surface sampling thin tissue sections |
| title | Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform |
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