Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Tumor-bearing hamsters were treated with thalidomide and were compared with controls. T...

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Veröffentlicht in:	Anticancer research 2012-07, Vol.32 (7), p.2703-2709
Hauptverfasser:	MOLINARI, Ana J, AROMANDO, Romina F, ITOIZ, Maria E, GARABALINO, Marcela A, MONTI HUGHES, Andrea, HEBER, Elisa M, POZZI, Emiliano C. C, NIGG, David W, TRIVILLIN, Veronica A, SCHWINT, Amanda E
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Angiogenesis Inhibitors - pharmacology Animals Biological and medical sciences BLOOD blood vessel normalization BLOOD VESSELS Blood Vessels - drug effects Blood Vessels - pathology Capillary Permeability - drug effects Case-Control Studies Cheek - blood supply Cheek - pathology Cricetinae DELIVERY Disease Models, Animal DRUGS DYES EVANS BLUE GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE hamster cheek pouch oral cancer model HAMSTERS HEAD IN VIVO Medical sciences Mesocricetus Microscopy - methods MORPHOLOGY Mouth Neoplasms - blood supply Mouth Neoplasms - drug therapy Mouth Neoplasms - therapy NECK NEOPLASMS Neovascularization, Pathologic - pathology oral cancer ORAL CAVITY Otorhinolaryngology. Stomatology OXYGEN Precancerous Conditions - blood supply REDUCTION thalidomide Thalidomide - pharmacology THERAPY Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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