Replication of N[superscript 2],3-Ethenoguanine by DNA Polymerases

The unstable DNA adduct N2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA po...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2014-10, Vol.51 ((22) ; 05, 2012)
Hauptverfasser:	Zhao, Linlin, Christov, Plamen P., Kozekov, Ivan D., Pence, Matthew G., Pallan, Pradeep S., Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES BIOCHEMISTRY CARCINOGENS DNA DNA ADDUCTS DNA DAMAGES DNA POLYMERASES DNA REPLICATION MODIFICATIONS MUTAGENESIS MUTATIONS VINYL CHLORIDE
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