Replication of N[superscript 2],3-Ethenoguanine by DNA Polymerases
The unstable DNA adduct N2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA po...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2014-10, Vol.51 ((22) ; 05, 2012) |
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| container_issue | (22) ; 05, 2012 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 51 |
| creator | Zhao, Linlin Christov, Plamen P. Kozekov, Ivan D. Pence, Matthew G. Pallan, Pradeep S. Rizzo, Carmelo J. Egli, Martin Guengerich, F. Peter |
| description | The unstable DNA adduct N2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA polymerases, in terms of both the biochemistry of the lesion and a structure of the lesion within a polymerase. |
| doi_str_mv | 10.1002/anie.201109004 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2014-10, Vol.51 ((22) ; 05, 2012) |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1043730 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES BIOCHEMISTRY CARCINOGENS DNA DNA ADDUCTS DNA DAMAGES DNA POLYMERASES DNA REPLICATION MODIFICATIONS MUTAGENESIS MUTATIONS VINYL CHLORIDE |
| title | Replication of N[superscript 2],3-Ethenoguanine by DNA Polymerases |
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