Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter

Huntington’s disease (HD), caused by a mutation of the corresponding gene encoding the protein huntingtin (htt), is characterized by progressive deterioration of cognitive and motor functions, paralleled by extensive loss of striatal neurons. At the cellular level, pathogenesis involves an early and...

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Veröffentlicht in:	Analytical chemistry (Washington) 2011-10, Vol.83 (20), p.7712-7720
Hauptverfasser:	Bonda, Markus, Perrin, Valérie, Vileno, Bertrand, Runne, Heike, Kretlow, Ariane, Forró, László, Luthi-Carter, Ruth, Miller, Lisa M, Jeney, Sylvia
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Ageing, cell death Allergology Amyloidosis Animals BASIC BIOLOGICAL SCIENCES Biochemistry, Molecular Biology Biological and medical sciences Biophysics BRAIN Brain - metabolism Brain - pathology Cell physiology Cells, Cultured Chemical Physics Chemical Sciences Corpus Striatum - cytology Corpus Striatum - metabolism Discriminant Analysis DISEASES Female Fundamental and applied biological sciences. Psychology Gene expression GENES Huntingtin Protein Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntingtons disease Immunology IN VIVO Inorganic chemistry Life Sciences LIPIDS Material chemistry Molecular and cellular biology MOTORS MUTANTS Mutation MUTATIONS NERVE CELLS Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Nuclear Proteins - genetics Nuclear Proteins - metabolism PATHOGENESIS PHOSPHORYLATION Physics PROTEIN STRUCTURE Protein Structure, Secondary PROTEINS Rats Rats, Wistar SPATIAL RESOLUTION Spectroscopy, Fourier Transform Infrared SYNCHROTRONS TRANSFORMATIONS
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