Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size
This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation. Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfi...
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| Veröffentlicht in: | Journal of computer assisted tomography 2010-03, Vol.34 (2), p.273-278 |
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| container_title | Journal of computer assisted tomography |
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| creator | Moritz, Regina Eaker, Diane R Langheinrich, Alexander C Jorgensen, Steven M Bohle, Rainer M Ritman, Erik L |
| description | This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation.
Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil and scanned (micro-CT). Noise was added to the CT projection data sets (to represent the radiation exposure of current clinical CT scanners) and then reconstructed to generate 3-dimensional images at different voxel sizes.
Higher CT values were detected because of contrast agent in vasa vasorum if voxel size was less than (150 microm)(3). Contrast in the main lumen increased the CT values dramatically at voxels greater than (100 microm)(3), whereas CT values of the same specimen without contrast in the main lumen remained constant.
Voxel sizes less than (200 microm)(3) are needed to quantitate arterial wall opacification due to vasa vasorum proliferation. |
| doi_str_mv | 10.1097/RCT.0b013e3181bb0d32 |
| format | Article |
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Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil and scanned (micro-CT). Noise was added to the CT projection data sets (to represent the radiation exposure of current clinical CT scanners) and then reconstructed to generate 3-dimensional images at different voxel sizes.
Higher CT values were detected because of contrast agent in vasa vasorum if voxel size was less than (150 microm)(3). Contrast in the main lumen increased the CT values dramatically at voxels greater than (100 microm)(3), whereas CT values of the same specimen without contrast in the main lumen remained constant.
Voxel sizes less than (200 microm)(3) are needed to quantitate arterial wall opacification due to vasa vasorum proliferation.</description><identifier>ISSN: 0363-8715</identifier><identifier>EISSN: 1532-3145</identifier><identifier>DOI: 10.1097/RCT.0b013e3181bb0d32</identifier><identifier>PMID: 20351520</identifier><language>eng</language><publisher>United States</publisher><subject>ARTERIES ; ARTERIOSCLEROSIS ; Cadaver ; COMPUTERIZED TOMOGRAPHY ; Coronary Angiography - methods ; Coronary Vessels - anatomy & histology ; Humans ; Imaging, Three-Dimensional ; In Vitro Techniques ; national synchrotron light source ; NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION ; PROLIFERATION ; RADIATIONS ; Radiographic Image Interpretation, Computer-Assisted ; Regression Analysis ; Tomography, X-Ray Computed - methods ; Vasa Vasorum - anatomy & histology ; Vasa Vasorum - diagnostic imaging ; X-Ray Microtomography</subject><ispartof>Journal of computer assisted tomography, 2010-03, Vol.34 (2), p.273-278</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c282t-31fcd817c583616dd18d9218a5101da9a5cafefc47e7567cee374200156bad813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20351520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1020220$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Moritz, Regina</creatorcontrib><creatorcontrib>Eaker, Diane R</creatorcontrib><creatorcontrib>Langheinrich, Alexander C</creatorcontrib><creatorcontrib>Jorgensen, Steven M</creatorcontrib><creatorcontrib>Bohle, Rainer M</creatorcontrib><creatorcontrib>Ritman, Erik L</creatorcontrib><creatorcontrib>Brookhaven National Laboratory (BNL) National Synchrotron Light Source</creatorcontrib><title>Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size</title><title>Journal of computer assisted tomography</title><addtitle>J Comput Assist Tomogr</addtitle><description>This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation.
Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil and scanned (micro-CT). Noise was added to the CT projection data sets (to represent the radiation exposure of current clinical CT scanners) and then reconstructed to generate 3-dimensional images at different voxel sizes.
Higher CT values were detected because of contrast agent in vasa vasorum if voxel size was less than (150 microm)(3). Contrast in the main lumen increased the CT values dramatically at voxels greater than (100 microm)(3), whereas CT values of the same specimen without contrast in the main lumen remained constant.
Voxel sizes less than (200 microm)(3) are needed to quantitate arterial wall opacification due to vasa vasorum proliferation.</description><subject>ARTERIES</subject><subject>ARTERIOSCLEROSIS</subject><subject>Cadaver</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>In Vitro Techniques</subject><subject>national synchrotron light source</subject><subject>NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION</subject><subject>PROLIFERATION</subject><subject>RADIATIONS</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Regression Analysis</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Vasa Vasorum - anatomy & histology</subject><subject>Vasa Vasorum - diagnostic imaging</subject><subject>X-Ray Microtomography</subject><issn>0363-8715</issn><issn>1532-3145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUcFq3DAUFKEh2WzzB6GIXnpyoidZtre3sqRJIRAS0rORpeddFVvaSnLo5h_yz9Gy2x5KLu_BY2YeM0PIBbBLYIv66nH5dMk6BgIFNNB1zAh-RGYgBS8ElPIDmTFRiaKpQZ6Ssxh_MQa1EOUJOeVMSJCczcjrw6Rcsr3VKlnvqO_ps4pqN3yYRmrQRZu21Do6TkOyRRysRqr9uJkSGpr86FdBbdZW52PwToUtVW5ld9cxfqXBD7hTfZdhR7VC-uz_4ECjfcGP5LhXQ8Tzw56Tn9-vn5a3xd39zY_lt7tC84anbK_XpoFay0ZUUBkDjVlwaJQEBkYtlNSqx16XNdayqjWiqEue7cuqU5ko5uTzXtfHZNuobUK91t451KkFxhnPCc3Jlz1oE_zvCWNqRxs1DoNy6KfY5ixzzhU0GVnukTr4GAP27SZka2GbtdpdWW0uq_2_rEz7dHgwdSOaf6S_7Yg3V3eUcg</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Moritz, Regina</creator><creator>Eaker, Diane R</creator><creator>Langheinrich, Alexander C</creator><creator>Jorgensen, Steven M</creator><creator>Bohle, Rainer M</creator><creator>Ritman, Erik L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20100301</creationdate><title>Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size</title><author>Moritz, Regina ; Eaker, Diane R ; Langheinrich, Alexander C ; Jorgensen, Steven M ; Bohle, Rainer M ; Ritman, Erik L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-31fcd817c583616dd18d9218a5101da9a5cafefc47e7567cee374200156bad813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ARTERIES</topic><topic>ARTERIOSCLEROSIS</topic><topic>Cadaver</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Vessels - anatomy & histology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>In Vitro Techniques</topic><topic>national synchrotron light source</topic><topic>NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION</topic><topic>PROLIFERATION</topic><topic>RADIATIONS</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Regression Analysis</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Vasa Vasorum - anatomy & histology</topic><topic>Vasa Vasorum - diagnostic imaging</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moritz, Regina</creatorcontrib><creatorcontrib>Eaker, Diane R</creatorcontrib><creatorcontrib>Langheinrich, Alexander C</creatorcontrib><creatorcontrib>Jorgensen, Steven M</creatorcontrib><creatorcontrib>Bohle, Rainer M</creatorcontrib><creatorcontrib>Ritman, Erik L</creatorcontrib><creatorcontrib>Brookhaven National Laboratory (BNL) National Synchrotron Light Source</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Journal of computer assisted tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moritz, Regina</au><au>Eaker, Diane R</au><au>Langheinrich, Alexander C</au><au>Jorgensen, Steven M</au><au>Bohle, Rainer M</au><au>Ritman, Erik L</au><aucorp>Brookhaven National Laboratory (BNL) National Synchrotron Light Source</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size</atitle><jtitle>Journal of computer assisted tomography</jtitle><addtitle>J Comput Assist Tomogr</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>34</volume><issue>2</issue><spage>273</spage><epage>278</epage><pages>273-278</pages><issn>0363-8715</issn><eissn>1532-3145</eissn><abstract>This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation.
Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil and scanned (micro-CT). Noise was added to the CT projection data sets (to represent the radiation exposure of current clinical CT scanners) and then reconstructed to generate 3-dimensional images at different voxel sizes.
Higher CT values were detected because of contrast agent in vasa vasorum if voxel size was less than (150 microm)(3). Contrast in the main lumen increased the CT values dramatically at voxels greater than (100 microm)(3), whereas CT values of the same specimen without contrast in the main lumen remained constant.
Voxel sizes less than (200 microm)(3) are needed to quantitate arterial wall opacification due to vasa vasorum proliferation.</abstract><cop>United States</cop><pmid>20351520</pmid><doi>10.1097/RCT.0b013e3181bb0d32</doi><tpages>6</tpages></addata></record> |
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| subjects | ARTERIES ARTERIOSCLEROSIS Cadaver COMPUTERIZED TOMOGRAPHY Coronary Angiography - methods Coronary Vessels - anatomy & histology Humans Imaging, Three-Dimensional In Vitro Techniques national synchrotron light source NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION PROLIFERATION RADIATIONS Radiographic Image Interpretation, Computer-Assisted Regression Analysis Tomography, X-Ray Computed - methods Vasa Vasorum - anatomy & histology Vasa Vasorum - diagnostic imaging X-Ray Microtomography |
| title | Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size |
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