An Aminopyridazine Inhibitor of Death Associated Protein Kinase Attenuates Hypoxia-Ischemia Induced Brain Damage

Death associated protein kinase (DAPK) is a calcium and calmodulin regulated enzyme that functions early in eukaryotic programmed cell death, or apoptosis. To validate DAPK as a potential drug discovery target for acute brain injury, the first small molecule DAPK inhibitor was synthesized and tested...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-03, Vol.13 (2003)
Hauptverfasser:	Velentza, A.V., Wainwright, M.S., Zasadzki, M., Mirzoeva, S., Haiech, J., Focia, P.J., Egli, M., Watterson, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSIS BRAIN CALCIUM CALMODULIN CRYSTAL STRUCTURE DEATH DESIGN ENZYMES IN VIVO LEAD COMPOUNDS MATERIALS SCIENCE PHOSPHOTRANSFERASES PROTEINS TARGETS
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