Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme

Ca2+/calmodulin-dependent protein kinase-II (CaMKII) is unique among protein kinases for its dodecameric assembly and its complex response to Ca2+. The crystal structure of the autoinhibited kinase domain of CaMKII, determined at 1.8 Å resolution, reveals an unexpected dimeric organization in which...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2005-12, Vol.123 (5), p.849-860
Hauptverfasser:	Rosenberg, Oren S., Deindl, Sebastian, Sung, Rou-Jia, Nairn, Angus C., Kuriyan, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Caenorhabditis elegans - enzymology Caenorhabditis elegans Proteins - chemistry Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - chemistry Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism CALMODULIN Calmodulin - metabolism CRYSTAL STRUCTURE Crystallography, X-Ray Dimerization Holoenzymes - chemistry Holoenzymes - genetics Holoenzymes - metabolism MATERIALS SCIENCE Models, Molecular Molecular Sequence Data PEPTIDES PHOSPHOTRANSFERASES Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary PROTEINS RESIDUES RESOLUTION SCATTERING Sequence Alignment THREONINE
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!