T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to {alpha}{beta} T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still...

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Veröffentlicht in:	Nature immunology 2010-07, Vol.6 ((11) ; 09, 2005)
Hauptverfasser:	Tynan, Fleur E, Burrows, Scott R, Buckle, Ashley M, Clements, Craig S, Borg, Natalie A, Miles, John J, Beddoe, Travis, Whisstock, James C, Wilce, Matthew C, Silins, Sharon L, Burrows, Jacqueline M, Kjer-Nielsen, Lars, Kostenko, Lyudmila, Purcell, Anthony W, McCluskey, James, Rossjohn, Jamie
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AMINO ACIDS BASIC BIOLOGICAL SCIENCES HISTOCOMPATIBILITY COMPLEX IMMUNITY PEPTIDES SHAPE
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