Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate

Ubiquitin C-terminal hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function. Although no cellular substrates have been identified for UCHs, their highly tissue-specific expression patterns and the association of UCH-L1 mutations with human disease strongly su...

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Veröffentlicht in:	The Journal of biological chemistry 2005-01, Vol.280 (2), p.1512-1520
Hauptverfasser:	Misaghi, Shahram, Galardy, Paul J., Meester, Wim J.N., Ovaa, Huib, Ploegh, Hidde L., Gaudet, Rachelle
Format:	Artikel
Sprache:	eng
Schlagworte:	ADDUCTS ALDEHYDES Amino Acid Sequence Binding Sites CRYSTAL STRUCTURE Crystallization Crystallography, X-Ray CYSTEINE Cysteine - metabolism DISEASES ENZYMES FLEXIBILITY Humans HYDROLASES HYDROLYSIS MATERIALS SCIENCE Models, Biological Models, Molecular Molecular Sequence Data MUTATIONS PEPTIDES Protein Binding Protein Conformation - drug effects RESOLUTION Rotation Sequence Alignment Substrate Specificity SUBSTRATES Ubiquitin - analogs & derivatives Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin - pharmacology Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - chemistry Ubiquitin Thiolesterase - isolation & purification Ubiquitin Thiolesterase - metabolism Ubiquitins - chemistry Ubiquitins - isolation & purification Ubiquitins - metabolism Ubiquitins - pharmacology YEASTS
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