Crystal Structure and DNA Binding of the Homeodomain of the Stem Cell Transcription Factor Nanog

The transcription factor Nanog is an upstream regulator in early mammalian development and a key determinant of pluripotency in embryonic stem cells. Nanog binds to promoter elements of hundreds of target genes and regulates their expression by an as yet unknown mechanism. Here, we report the crysta...

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Veröffentlicht in:	Journal of molecular biology 2008-02, Vol.376 (3), p.758-770
Hauptverfasser:	Jauch, Ralf, Ng, Calista Keow Leng, Saikatendu, Kumar Singh, Stevens, Raymond C., Kolatkar, Prasanna R.
Format:	Artikel
Sprache:	eng
Schlagworte:	AFFINITY Amino Acid Sequence AMINO ACIDS Animals CRYSTAL STRUCTURE Crystallography, X-Ray DNA DNA binding DNA-Binding Proteins - chemistry FUNCTIONALS GENES homeodomain Homeodomain Proteins - chemistry MATERIALS SCIENCE Mice Models, Molecular Molecular Sequence Data MUTAGENESIS Nanog Nanog Homeobox Protein pluripotency Promoter Regions, Genetic PROMOTERS Protein Structure, Tertiary RESIDUES Sequence Alignment SPECIFICITY STEM CELLS TARGETS transcription factor TRANSCRIPTION FACTORS
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